(also called KEGG BRITE) that capture the functional hierarchies of various biological objects (i.e., enzymes). These high-centrality nodes that provide generalized type description of related nodes may probably bring useless noises rather than benefits. For example, in the scenario of the cold ...
epilepsy and is thought to work through an interaction withsodiumchannels—a type ofion channelin thecell membrane, characterized by its selectivity for sodium. Thebarbituratesand thebenzodiazepinesact as antiepileptics byenhancingthe effectiveness of the inhibitoryneurotransmittergamma-aminobutyric acid (GABA...
acid residue on the antibody. Antibodies have been engineered with two site-specific (light or heavy chain) cysteine residues to allow two drugs per antibody when a payload connected to amaleimideis added to the thio-engineered antibody. Thedrug conjugateretains the interchaindisulfide bonds,...
agonists for this receptor must be able to cross the cell membrane. The drug-receptor complex acts on specific regions of the genetic materialdeoxyribonucleic acid(DNA) in the cell nucleus, resulting in an increased rate ofsynthesisfor some proteins and a decreased rate for others. Steroids genera...
Only one case was in need for hospitalization (a 18-year-old girl, treated with the combination of amoxicillin and clavulonic acid). All data, including descriptions of ARA events (upon which classification of severity reaction was made) and diagnoses of diseases, were based on the native ...
The polymers that constitute the backbone of a hydrogel can be divided into naturally derived proteins such as collagen, gelatin, fibrin, hyaluronic acid, alginate and agarose or synthetic polymers such as poly(ethylene glycol) (PEG) and poloxamers (Pluronic® and Lutrol®). In the ligh...
(cholecalciferol and glatiramer) were repositioned from MS to CD. In the following 2008–2009, additionally, four drugs were repositioned (tacrolimus and dexamethasone from MS to CD; zoledronic acid and prednisolone from CD to MS). As described above, we found the tendency thatRgenesurges ...
Nicotinic acid (also called niacin), a water-soluble B vitamin, improves blood levels of all lipoproteinswhen given in doses well above the vitamin requirement. Nicotinic acid lowers total cholesterol, LDL cholesterol, andtriglyceride levels, while raising HDL cholesterollevels. Nicotinic acid reduces...
the viral nucleic acid may remain in the host cell without causing replication of the virus and damage to the host (viral latency). In other cases, the production of virus by the host cell may cause the death of the cell. A major problem in treating some viral diseases is that latent ...
also obtained that did not meet all the defined selection criteria and therefore were not taken into account for further evaluation in this study but can become interesting candidates for subsequent studies. Some of these areribavirin,sodium cromoglycate,chlorzoxazone,ciprofloxacin,valproic acid,tadalafil...