Kulmatycki, Novel orally swallow- able intellicap R device to quantify regional drug absorption in human gi tract using diltiazem as model drug, AAPS Pharm- SciTech 15 (6) (2014) 1490-1497.Becker, D., Zhang, J., Heimbach, T., Penland, R.C., Wanke, C., Shimizu, J., Kulmatyc...
Transdermal Absorption: A Unique Opportunity for Drug DeliveryThe amount of drug absorbed from the gastrointestinal (GI) tract into the systemic circulation with conventional tablet and capsule dosage forms is dependent on the quantity and type of food in the stomach, GI motility and GI microbial ...
This review provides an overview of GI tract properties in special populations compared to healthy adults and discusses how drug absorption is affected by these conditions. Particular focus is directed towards non-disease dependent conditions (age, sex, ethnicity, genetic factors, obesity, pregnancy),...
In such a way it is necessary for the carrier to protect the drug against the hostile and degrading milieu of the GI tract while increasing the residence time (e.g. bioadhesion) and target specific cells to enhance absorp- tion which will most likely require less frequency regi- mens. A ...
However, the link of colonic factors variability (transit time, fluid composition, microbiome), sex differences (male vs. female) and gut-related diseases (chronic constipation, anorexia and cachexia) to drug absorption variability has not been firmly established yet. At the same time, a way to...
Models to identify drug effects on GI function cover GI motility, nausea and emesis liability, secretory function (mainly gastric secretion), and absorption aspects. Both in vitro and in vivo assessments are described in this chapter. Drug-induced effects on GI function can be assessed in stand-...
theyimprovedbioavailability,absorbedreadilyin upperpartofGItract (GargandGupta,2008). Theseincludes:Actingagentswhichactsin stomach,primarilyabsorbedinthestomach,poorly solubleatanalkalinepH,narrowwindowof absorption,absorbedrapidlyfromtheGItract, degradeinthecolon.Thereare various advantages of gastro retentive ...
et al. Novel orally swallowable IntelliCap device to quantify regional drug absorption in human GI tract using diltiazem as model drug. AAPS PharmSciTech 15, 1490–1497. https://doi.org/10.1208/s12249-014-0172-1 (2014). Article CAS PubMed PubMed Central Google Scholar Nikolaidis, L. A...
Human intestinal permeability is a key drug-related parameter governing the gastrointestinal (GI) drug absorption process. Due to the established correlation between human effective jejunal permeability (Peff) and the fraction of the administered oral dose that becomes absorbed in the GI tract (fabsorfa...
Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on external stimuli