Dronedarone, an investigational antiarrhythmic agent being studied for the management of AF and atrial flutter, has a pharmacologic mechanism of action that is similar to that of amiodarone, but dronedarone lacks an iodine moiety, which may result in less thyroid and pulmonary toxicity. During ...
A link to download a PDF version of the drug profile will be included in your email receipt. At a glance Originator sanofi-aventis Developer Sanofi Class Antiarrhythmics; Benzofurans; Class III antiarrhythmics; Ischaemic heart disorder therapies; Small molecules Mechanism of Action Calcium ...
Mechanism Of Action The mechanism of action of dronedarone is unknown. Dronedarone has antiarrhythmic properties belonging to all four Vaughan-Williams classes, but the contribution of each of these activities to the clinical effect is unknown. ...
The mechanism of action of DRONEDARONE HYDROCHLORIDE involves its ability to prolong the cardiac action potential and inhibit multiple ion channels, resulting in the stabilization of the heart's electrical activity. Storage Conditions: Store in a cool and dry place. View all 3.2 GHS ...
Mechanism of antiarrhythmic action not fully elucidated; exact contribution of activities in each of the 4 Vaughan-Williams antiarrhythmic classes to the clinical effect of the drug unknown. Benzofuran derivative structurally related to amiodarone, but with structural modifications that include removal of ...
AmiodaroneAnticoagulantsAtrial fibrillationCardiac drugsDabigatranDosageDronedaroneMechanism of actionRivaroxabanToxicityPURPOSE: To compare and contrast the pharmacology,... Cheng Judy W.M - 《Am J Health Syst Pharm》 被引量: 38发表: 2010年 Treating arrhythmias: an expert opinion. Significant progress has...
Dronedarone, an investigational antiarrhythmic agent being studied for the management of AF and atrial flutter, has a pharmacologic mechanism of action that is similar to that of amiodarone, but dronedarone lacks an iodine moiety, which may result in less thyroid and pulmonary toxicity. ...
Dronedarone has a multifaceted mechanism of action similar to that of amiodarone. Dronedarone works by blocking potassium, sodium, and calcium channels and exhibits antiadrenergic properties. The drug has been evaluated at doses of 400, 600, and 800 mg twice daily. It prolonged the time to ...
Inhibition of filovirus entry was observed with most but not all cell types tested and was accentuated by the pre-treatment of cells, indicating a host cell-directed mechanism of action. The New World arenavirus Guanarito was also inhibited by amiodarone while the Old World arenavirus Lassa ...
Use of dronedarone or its salt for the preparation of a medicament for the prevention of mortality and/or cardiovascular hospitalizations in patients having a history of atrial fibrillation or atrial flutter, is claimed. ACTIVITY : Cardiovascular-Gen; Metabolic. MECHANISM OF ACTION : Potassium channel...