6a) versus 20.74% (range 2.66–50.94%) for PE2 founder mice (Fig. 6b; Additional file 1: Supplementary Fig. 5). Despite a significantly higher frequency of on-target editing, all of the HDR founders showed undesired indels (mean of 40.11%, range 0.91–93.91%) (Fig. 6a). In contrast...
In the Northern Hemisphere, the surface of south-facing slopes orients toward the sun and thus receives a greater duration and intensity of solar irradiation, resulting in a relatively warmer, drier microclimate and seasonal environmental extremes. This creates potentially detrimental conditions for ever...