D138N, P = 1.67e-08; WT vs. K166A, P = 1.31e-08. c Representative chromatograms of products of the HPRT1 kinase assay. d Michaelis-Menten curve of HPRT1 for AICA. Reactions were performed by mixing purified active HPRT1 and AICA. Data represent the mean ± SD from ...
It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of physiological osteoclast differentiation. However, the specific drivers and mechanisms driving inflammatory osteoclast differentiation under pathological conditions
25,32. Moreover, Pin1 is highly enriched in breast TICs/CSCs to drive their self-renewal and tumor initiation33,34,35. Finally, Pin1 has a critical role in viral, bacterial, and parasitic infections and their related malignancies36. Notably, Pin1−/− mice display no obvious...