Future directions In parallel with the development of engineered T cell immunotherapy, the field of cancer immunotherapy as a whole has made great leaps recently, particularly in the form of checkpoint blockade antibodies. In direct rela- tion to a T cell's ability to achieve anti-tumor function...
There is increasing focus on how best to optimize patient outcomes and achieve cost-effective care—not just in the short-term, in-hospital, or 30-day time frame following a cardiac surgical procedure, but also long-term survival and freedom from rehospitalizations and reinterventions. Importantly...
21,22,−23]. Briefly, PHH of prematurity is caused by the rupture of blood vessels within the germinal matrix, a transient anatomical region in the developing human brain home to neural and glial precursor cells. Extravasation of blood into the ventricles constitutes intraventricular hemorrhage...
While TCR gene-engineered T-cell therapy has certainly proven to be potent, and efficacious in some cases, it faces a number of caveats. First and foremost is that it is necessarily restricted to a subset of patients. Not only do patients' tumors have to express the protein of interest, t...