Recurrent driver mutations inFLT3occur in approximately one-third of patients with de novo AML as internal tandem duplications (ITD) in the juxtamembrane domain or point mutations in the activation loop of the tyrosine kinase domain (Fig.1a), which are screened for in routine diagnostics of AML32...
Elected on the promise of financial and social reform, FDR would go on to become the longest-serving president in history, the architect of the New Deal, the founder of America's social safety net, and the man who would lead the country out of the Great Depression and through World W...
For surface staining, cells were suspended in FACS buffer and stained with the antibody cocktail for 30 min at room temperature in the dark. The pH1047L-tetramer-PE/APC were used for the identification of antigen-specific CD8+T lymphocytes, which were generated using the PE QuickSwitch Quant H...
Gohran of Russia The Kremlin’s Diamond Depository dates back to the reign of Peter I, who decreed for the most valuable treasures to become property of the Russian state, not only of the Royal Family. From then on, precious regalia, insignia and secular jewelry belonging to several generatio...
. . effectively it’s a plus pack that you can get on the road car because of some of the legal hoops we have to go through in order to put the car on the road.” “It’s near the road car, in truth,” Newey added. “It’s the road car with a slightly dif...