Furthermore, all the three missense variants have not been reported in the following SNP database: SNP database (dbSNP) (http://www.ncbi.nlm.nih.gov/projects/SNP), the 1000 Genomes Project (http://www.1000genomes.org), HGVB (http://www. genome.med.kyoto-u.ac.jp/SnpDB/index.html)...