Dried Blood Spots (DBS) technology has become a valuable tool in medical studies, however, in veterinary and biological research DBS technology applications are still limited. Up-to-date no review has comprehensively integrated all the evidence existing across the fields, technologies and animal specie...
In addition to the venipuncture, capillary blood samples were obtained at the same moment by the finger stick technique. If necessary, the skin site was warmed before the puncture with a gel pack of 42 °C for maximal 3 min. First, the puncture site was cleaned with a tissue containing i...
The samples were analyzed using a biochemistry analyzer (TBA-120FR, Toshiba Medical System Co. Ltd., Tokyo, Japan) for the following parameters: total protein, albumin, albumin/globulin ratio, total bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, creatinine, blood ...
Surgical operations were carried out under general anesthesia with 3% (w/v) pentobarbital (50 mg/kg). After shaving and sterilizing the local skin, the median incision of the lower abdomen was selected for surgery. The rabbits in OVX group were underwent bilateral OVX surgery, and the rabbits...
By considering the complexity of the spray drying process, quality by design approach in the manufacturing process was, therefore important and required to carefully optimize the spray drying technology for long term stability of solid drug form under the test60. ...
The tissue was washed using sterile saline (0.9% w/v, Fresenius Kabi, Langenhagen, Germany) and separated from blood clots. Then, part of the AM was stretched on a mesh support (Sanatyl; Tylex, Letovice, Czech Republic) and cut to 2 × 2 cm. These fresh specimens (with no ...
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