Early repeated dose-range finding (DRF) toxicology studies, usually conducted in rodent and non-rodent animal species, seek to provide the earliest assessment of the toxicity profile of new chemical entities (NCE) using well-designed and validated nonclinical study designs. Thus, the DRF study ...
The increase in microplastic exposure since the pandemic raises concerns about long-term health effects, emphasizing the need for research on their toxicity and potential risks [7, 8]. Addressing this issue also requires improving waste management and creating policies that limit plastic pollution in ...
This article focuses on the various types of acute toxicity study designs, their utility in pharmaceutical product testing, their limitation, and the resultant sample data. Keywords: acute toxicity testing; dose range finders (DRFs); dose probe studies; median lethal dose (LD 50 ) test; minimum...
The purpose of this bridging phase I study was to characterize the toxicity, pharmacokinetics, and antitumor effects of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory solid tumor patients. DRF-1042 was given daily for 5 consecutive days for 2 weeks, repeated every...