非随机临床研究的证据等级较低，因为对照组是从数据库里面选出来的患者，无法排除主观因素。来自安卓APP...
你在这版块找找,我好像看到塞不行,对tp53突变还不如安慰剂,不确定,你可以用tp53做关键字搜索下 2022-11-2 22:56:59·来自四川 碧海蓝天1939 祝福永远cr 2022-11-3 02:27:21·来自上海 吟听美好 主治医生说有的点突变有的没事,有的点突变两年之内必复发。但哪几个点再问基因检测公司 2022-11-3 07:...
git clone https://github.com/drramki-chop/EDM.git conda env create -f edm_conda_env.yml conda activate edm_environment If you'd like to install conda from scratch, follow the protocol here: https://conda.io/projects/conda/en/latest/user-guide/install/linux.html Step 2: Install EDM pa...
因此,中心在吴德沛教授和李彩霞教授带领下开展了一项BTK抑制剂泽布替尼联合R-CHOP(ZR-CHOP),在结外累及non-GCB亚型DLBCL的注册临床研究(NCT04835870),并以R-CHOP方案对照,探索进一步提高DLBCL整体治疗的安全性和疗效的改善。 结果显示,治疗反应率ORR和完全缓解率CR在ZR-CHOP组和R-CHOP组分别是91.3%、82.6%和68.1%...
R-CHOP是一个非常成功的联合化疗方案,但是很少有详细的药物学研究,对于多药方案耐药的机制仍然未明。Palmer等人采用药理学分析和功能基因组学研究发现方案中的五种药物几乎不存在交叉耐药,提示联合方案的总体疗效是由非重叠耐药机制的活性药物组成。 就单个化疗药物的耐药机制而言,一些研究表明肿瘤micro RNA及其靶点具有潜...
Ixazomib promotes CHOP-dependent DR5 induction and apoptosis in colorectal cancer cells.doi:10.1080/15384047.2018.1529095Dan YueXun SunTaylor & FrancisDan,Yue,Xun,etc.Ixazomib promotes CHOP-dependent DR5 induction and apoptosis in colorectal cancer cells.[J].2018....
Transcription factor CHOP was subsequently transactivated by ATF4 and further induced the expression of DR5 to activate caspase-8 and induce extrinsic apoptosis. Moreover, the entire neddylation pathway was hyperactivated in ESCC and was negatively associated with patient overall survival.Conclusions: ...
方法:选取2014年9月~2017年1月在本院接受R-CHOP方案治疗的初治DLBCL患者48例为试验组,另选取同期接受CHOP方案化疗的初治DLBCL患者44例为对照组.于初诊时,每疗程化疗后采集患者空腹血检测外周血中免疫球蛋白,T淋巴细胞亚群,β2微球蛋白及Treg的水平.结果:(1)治疗前,试验组与对照组免疫球蛋白IgA,IgG,IgM含量...
In addition to HCT116 cells, inhibition of CHOP or DR5 induction also attenuated THG-induced cell death in other cancer cell lines including LNCaP, A2780S, and DU145, indicating that CHOP and DR5 are critical for ER stress-mediated apoptosis in human carcinoma cells. Furthermore, we ...
molecules Article Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP Mi-Yeon Jeon 1, Kyoung-jin Min 1, Seon Min Woo 1, Seung Un Seo 1, Yung Hyun Choi 2 , Sang Hyun Kim 3, Dong Eun Kim 4, Tae-Jin Lee 5, ...