The HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice (MHC-II-/-), and control non-HLA-DR15-relevant-Tg mice were immunized with a set of overlapping PLP peptides or with recombinant soluble PLP for induction of "humanized" MS-like disease, as well as for ex-vivo analysis of immunogenic/imm...
目的探讨典型猝倒并人类白细胞抗原(HLA)- DQB1*0602(+)对发作性睡病患者脑脊液下丘脑分泌素(HCRT)-1降低的预测价值。 方法收集2003年3月至2017年3月在北京大学人民医院和北京大学国际医院睡眠中心就诊的发作性睡病患者共165例,对所有入组患者进行DQB1*0602基因及脑脊液HCRT-1测定。依据能否同时满足猝倒并DQB1*...
分别测定其HLA-DQB1*0602状态、低O_2高CO_2(△VE/△PCO_2,L/min/mmHg)反应性和低O_2(△VE/△SaO_2,L/min/%SaO_2)反应性。下丘脑分泌素缺乏的判定是通过检测脑脊液下丘脑分泌素水平(37名患者)或通过检测HLA-DQB1*0602(95%的HLA-DQB1*0602阳性患者伴有脑脊液水平降低)。所有患者和49%的正常对照都...
HLA—DRB1 ＊1501和DQB1 ＊0602与新疆哈萨克族HPV感染及食管癌发生的相关性研究
In the present study, we tested 19 Caucasian and 28 Black American narcoleptics for the presence of the human leucocyte antigen (HLA) DQB1*0602 and DQA1*0102 (DQ1) genes using a specific polymerase chain reaction (PCR)-oligotyping technique. A similar technique was also used to identify DRB1...
探讨HLADRB1*1501和DQB1*0602与新疆维吾尔、汉族妇女HPV感染及宫颈癌发生的相关性。PCR-SSP和PCR检测287例浸润性宫颈癌(维族192例,汉族95例)及297例正常宫颈组织(维族203例,汉族94例)中DRB1*1501和HLADQB1*0602的分布频率和HPV16DNA。维族HPV16阳性NILM组中DRB1*1501基因频率高于HPV16阴性NILM组(...
6、HLA检测证实DQB1*0602或DR2阳性。 7、没有其他可以解释以上症状的躯体和精神方面疾病。 温馨提示:以上就是专家对于发作性睡病如何诊断的相关介绍,希望对大家有所帮助。专家表示,如果孩子又出现上述的现象,一定要及时的到相关医院进行必要的检查,以免错过了最佳的治疗时机,给生活带来不必要的影响。
0.877.HLA-DQB1*0602 分别为:94.2%,75.4%,92%,0.696.当将 MSLT 中 MSL 的值降低时,其特异性,阳性预测值升高,但灵敏性,约登指数下降.MSLT联合DQB1*0602预测发作性睡病的灵敏性,特异性,阳性预测值和约登指数分别是:88.3%,100%,100%,0.883.MSLT*联合 DQB1*0602 时,随 MSL 减少,其特异性和阳性预测值升高...
Multiple Sclerosis (MS) is a demyelinating disease associated with the HLA-DR2-related haplotype DRB1*1501, DQB1*0602 in Caucasoids and with DQB1*0602 in DR2-positive Cantonese. However, many MS patients do not have the high-risk HLA-D determinants and alternative genes may contribute to th...