由于编码DPD酶的DPYD基因发生杂合突变,导致DPD酶的活性降低,进而使希罗达()代谢减慢,蓄积在体内引起毒性反应。因此,在使用希罗达前,建议将DPYD*2A基因检测作为常规检查。
用于检测DPYD*2A遗传多态性的引物,探针及检测试剂盒,涉及体外核酸检测.利用不同的荧光基团标记的探针可同时检测样品中基因DPYD*2A(rs3918290)多态性.实现单管封闭可同时检测多个SNP位点,克服传统荧光法检测通量不高的缺陷,减少交叉污染的几率;操作简便,检测快速;检测结果直观,根据不同的荧光信号产生的扩增曲线即可定性...
Upfront genotyping of DPYD*2A to individualize fluoropyrimidine therapy: a safety and cost analysis. J Clin Oncol 2016;34:227-34.Deenen MJ, Meulendijks D, Cats A, Sechterberger MK, Severens JL, Boot H, et al. Upfront Genotyping of DPYD*2A to individualize fluoropyrimidine therapy: a...
用于检测DPYD*2A遗传多态性的引物,探针及检测试剂盒,涉及体外核酸检测. DPYD * 2A for detecting a genetic polymorphism primers, probes and detection kit, to detect the nucleic acid in vitro. 利用不同的荧光基团标记的探针可同时检测样品中基因DPYD*2A(rs3918290)多态性. With a different fluorophore-...
DPYD genotypingDPYD*2AFluorouracil (5FU)CapecitabineFluoropyrimidines are used in chemotherapy combinations for multiple cancers. Deficient dihydropyrimidine deshydrogenase (DPD) activity can lead to severe life‐threatening toxicities. DPYD*2A polymorphism is one of the most studied variants. The study ...
Enzyme DPD has a key function for 5-FU metabolism (degradation and inactivation) and is encoded by DPYD gene . In the majority of cases, a G to A mutation in the splicing recognition sequence of intron 14 ( IVS14+1G>A ) of the DPD-encoding gene DP ......
DPYD*2A-guided fluoropyrimidine therapy reduces toxicityReactions Weekly -doi:10.1007/s40278-015-11351-3NoneSpringer International PublishingReactions Weekly
86 DPYD*2A variant carriers who received a full fluoropyrimidine dose. For 37 out of 40 DPYD*2A carriers, a matched control could be identified. Compared to matched controls, reduced doses did not negatively affect overall survival (median 27 months versus 24 months, P=0.47) nor progression‐...
62例健康志愿者DPYD*2A基因型信息.DPYD*1/*1,*1/*2A和*2A/*2A基因型的发生率在黄种人群(n=1011)中分别为99.8%,0.2%和0,在白种人群(n=4290)中分别为98.6%,1.4%和0,在黑种人群(n=1161)中分别为100.0%,0和0,在总体人群(n=6462)中分别为99.1%,0.9%和0.结论不同种族之间DPYD*2A基因型发生率...
Cancer Chemother Pharmacol. Jan 2018;81(1):119-129. PMID 29134491Chowdhury, Surid Mohammad,Islam,etc.DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer[J].2018,81(1)....