are the results of multiple studies and can improve the blood glucose-lowering effect and have significant effects on a variety of patients who are ineffective in lowering blood glucose. Based on this, this article mainly reviews the mechanism of action of DPP4 inhibitors in the treatment of ...
However, the mechanism of action remains unclear. The OV A2780 cells were treated using nobiletin, cell viability was examined using a cell counting kit-8 experiment, and cell migration was examined with a wound healing experiment. Nobiletin targets were retrieved from target databases. ...
Moreover, hVSMCs are involved in the ongoing low-grade inflammation within arteriosclerotic lesions by recruitment of immune cells [9]. However, the underlying mechanism of hVSMC dysfunction taking place in type 2 diabetes and obesity is not fully understood. The aim of the present study was to...
A. Vella Mechanism of action of DPP-4 inhibitors – new insights J. Clin. Endocrinol. Metab., 97 (2012), pp. 2626-2628 CrossrefView in ScopusGoogle Scholar Wang et al., 2014 Z. Wang, C. Grigo, J. Steinbeck, S. von Horsten, K. Amann, C. Daniel Soluble DPP4 originates in part...
Kim YB, Kopcho LM, Kirby MS, Hamann LG, Weigelt CA, Metzler WJ, Marcinkeviciene J: Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118). Arch Biochem Biophys. 2006, 445: 9-18. Article CAS PubMed Google Scholar Ajami K...
Interestingly, glucocorticoids highly stimulated macrophage migration through a DPP4-dependent mechanism [132]. In experimental mice, it was shown that the promoter region of DPP4 was hyperacetylated during and after dexamethasone treatment [133]. The upregulation of DPP4 by glucocorticoids might ...
Signaling mechanism of extracellular RNA in endothelial cells. FASEB J. 2009, 23, 2100–2109. [CrossRef] [PubMed] 15. Chandraratne, S.; von Bruehl, M.L.; Pagel, J.I.; Stark, K.; Kleinert, E.; Konrad, I.; Farschtschi, S.; Coletti, R.; Gartner, F.; Chillo, O.; et al...
The most recent therapeutic choices for the management of T2DM are dipeptidyl peptidase 4 (DPP-4) inhibitors, glucagon-like peptide 1 (GLP-1) receptor agonists and sodium鈥揼lucose cotransporter 2 (SGLT-2) inhibitors. In this article, we summarize the mechanism of action, the advantages and ...
In this study, we aimed to explore the underlying mechanism of circDPP4 in PCa progression. Levels of circDPP4, microRNA (miR)-497-5p, glutamate dehydrogenase 1 (GLUD1), proliferating cell nuclear antigen (PCNA), BCL2 associated X, apop-tosis regulator (Bax), E-cadherin and Ki67 were ...
To assess the efficiency of the combined therapy with metformin and dapagliflozin, a new oral anti-diabetic drug with an insulin-independent mechanism of action, in the treatment of type-2 diabetes mellitus (T2DM) compared to DPP4 inhibitors, sulphonylureas and thiazolidindiones, also combined ...