Side effects with the DPP-IV inhibitors are relatively few. Stein and colleagues[14]reported pooled safety data from 9 completed phase 2B and 3 studies, including 5141 persons receiving sitagliptin or a comparator, and hypoglycemia was considerably less frequent than with sulfonylureas. Side effects ...
The increasing prevalence of diabetes has led to reducing hyperglycemia through mechanisms other than the conventional mechanism, such as α-amylase and α-glucosidase inhibition. In recent years, medicinal drugs focusing on inhibiting dipeptidyl peptidase IV (DPP IV) and protein tyrosine phosphatase 1B...
DPP-IV inhibitors are an efficacious drug employed in the treatment of hyperglycemia processes. However, these drugs can cause undesirable side effects. Thus, the development of new natural hypoglycemic drugs with low side effects is a valuable strategy to be applied in therapeutic interventions....
【16】Byrd JB,Touzin K,sile s,et a1.DiPePtidyl P印tidase IV jn a“giotensin— conVerting enzyme inhibitor associated a“gioedema【JJ.HyPertension,2008, 51(1):14卜147. 【17】Toyoda—Akui M,Y0komo—H,Kaneko F,et a1.A case ofdrug_induced hepaⅡc 叫“ryassociated with sitagliPtin?.Int...
Incretin mimetics and DPP-IV inhibitors: new paradigms for the treatment of type 2 diabetes. Hinnen,D.,Nielsen,L.L.,Waninger,A.Incretin mimetics and DPP-IV inhibitors: new paradigms for the treatment of type 2 diabetes. J Am Board Fam Med ... LL Nielsen - 《Journal of the American Boa...
We conducted a prospective observational study of a cohort of 60 patients with T2DM and CKD stage IV, selecting a sample of 15 patients taking an inhibitor of DPP-4 and comparing it with those who took therapy "old" drugs, despite having similar characteristics of CKD. In both groups, we ...
Discovery of JANUVIA TM (Sitagliptin), a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type2 Diabetes. The emergence of glucagon-like peptide 1 (GLP-1) as a well validated approach to the treatment of type 2 diabetes and preclinical validation of dipeptidyl ... NA Thornberry...
Forum雠 Special 瓤多 Adversereaction inhibitors drug ofDPP一4 DPP一4抑制剂不良反应 安徽省立医院内分泌科胡圆圆叶山东 1 04 中国分类号587 文献标识码A 文章编号1672—2809C2011)21—0046 美键词DPP一4抑制剂+胰升糖素样肚1葡萄糖促胰岛素多肽 宴卤尿病是一种因胰岛紊绝 多效的酶,在体内分布广泛.其具...
DPP-IV Inhibitors are devoid of such major side effects. Designing pyrimidinedione-based compounds may probably give safe pharmacological profile with significant antidiabetic activity. Compounds are designed rationally and molecular docking studies are performed on DPP-IV subunits by PyRx 0.8 (Autodock ...
3) exenatide OR lixisenatide OR liraglutide OR semaglutide OR albiglutide OR dulaglutide OR efpeglenatide; 4) randomized controlled trial; 5) cardiovascular outcome OR cardiovascular safety OR cardiovascular events; 6) DPP4 OR DPP-4 OR DPP-IV; 7) dipeptidyl peptidase-4; and 8) alogliptin OR sax...