Thornberry NA, Gallwitz B (2009) Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4). Best Pract Res Clin Endocrinol Metab 23: 479- 486.Nancy A. Thornberry,Baptist Gallwitz.Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)[J]. Best Practice & Research ...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are glucose-lowering drugs for type 2 diabetes mellitus (T2DM). We investigated whether evogliptin® (EVO), a DPP-4 inhibitor, could protect against diabetic cardiomyopathy (DCM) and the underlying mechanisms. Eight-week-old diabetic and obese db/db...
关键词:马氏珍珠贝,二肽基肽酶 IV,药效团模型,肽,分子对接 中图分类号:TS201.4 文献标识码:A 文章编号:1002−0306(2021)16−0001−07 DOI: 10.13386/j.issn1002-0306.2020120273 Virtual Screening and Mechanism of Action of DPP-IV Inhibitory Peptides from Pinctada fucata ...
ANDERSEN E S, DEACON C F, HOLST J J. Do we know the true mechanism of action of the DPP-4 inhibitors?[J]. Diabetes Obesity and Metabolism,2018,20(1):34−41.doi:10.1111/dom.13018 [14] GOR D, LEE T A, SCHUMOCK G T, et al. Adherence and persistence with DPP-4 inhibitors ve...
作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 As dipeptidyl peptidase iv (dpp-iv) inhibitors 3- (3-amino-piperidin-1-yl) -5-o... 本发明提供了作为二肽基肽酶(DPP-IV)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物,及其药物组合物与...
Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used treatments for patients with type 2 diabetes mellitus (T2DM). Both anti-diabetic treatments function by playing key modulatory roles in the incretin system.
The invention relates to compounds of formula (I) wherein R1, R2, R3 and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the preparation of such compounds as well as the production and use thereo...
Abstract : Dipeptidyl peptidase — 4 (DPP-4) inhibitors can alleviate transformation of vascular endothelial cells into mesenchymeinpatientswithpulmonaryarteryhypertension (PAH ), reduceproliferationand migrationoffibro- blasts , preventfibrosis , andtherebyprolongoreveninhibitentering...
5.Shao S, Xu Q, Yu X, Pan R, Chen Y. Dipeptidylpeptidase 4 inhibitors and their potential immune modulatory functions.Pharmacol Ther. 2020 May;209:107503.6.https://clinicaltrials.gov/ct2/home 7.Makrilakis K. The Role of DPP-4 Inhibitors in the Treatment Algorithm ofType 2 Diabetes ...
DPP-IV INHIBITORS 专利名称：DPP-IV INHIBITORS 发明人：Edwards, Paul John,Lòpez-Canet,Meritxell,Feurer, Achim,Cerezo-Galvez,Silvia,Matassa, Victor Giulio,Nordhoff,Sonja,Rummey, Christian 申请号：EP03028257.8 申请日：20031209 公开号：EP1541148A1 公开日：20050615 专利内容由知识产权出版社提供 摘要：...