DPD 催化 5-FU 和尿嘧啶转化为 5,6-二氢尿嘧啶,这一过程是 5-FU 代谢的速率限制步骤。该酶的活性直接影响 5-FU 的药物浓度和疗效,因此,DPD 的缺陷可能导致 5-FU 在体内的积累,从而导致毒性反应增加[2]。此外,DPD 的活性与患者对化疗的反应...
该研究对患者的U值、UH2/U比值、基因型特征以及5-FU的代谢情况进行了详细的数据分析。结果显示，患者的U值或UH2/U比值与DPYD基因型缺乏之间并未发现紧密关系，这与先前的研究结果形成对比。同时，该研究还首次指出，5-FU的清除率与DPYD基因型之间也缺乏相关性。然而，该研究的一个重要发现是，当U值或UH2/U比值...
1. Tsalic, M., et al.,Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): a prospective study in colorectal cancer patients.Am J Clin Oncol, 2003.26(1): p. 103-6. 2. Launay, M., et al.,Upfront Dpd Deficiency Detection to Secure 5-Fu Admi...
DPD-based adaptive dosing of 5-FU in patients with head and neck cancer : impact on treatment and toxicity. Cancer Chemother Pharmacol 2011 ; 67 : 49-56.Yang CG,Ciccolini J,Blesius A,et al.Dpd-based adaptivedosing of 5-fu in patients with head and neck cancer:impact on treatment ...
[摘要]背景与目的:结直肠癌作为常见的消化系统恶性肿瘤之一,其化疗与耐药一直以来备受关注,5-氟尿嘧啶(5-fluorouracil,5-FU)是结直肠癌的一线化疗药物,其疗效常因耐药或不良反应而受到影响。二氢嘧啶脱氢酶(dihydropyrimidine dehydrogena...
Dihydropyrimidine dehydrogenase (DPD) degrades over 80% of administered 5-fluorouracil (5FU), thereby regulating the efficacy of this commonly used anticancer agent. DPD activity is highly variable (8-21-fold) and individuals with reduced activity have a high risk of 5FU toxicity. DPYD encodes ...
et al., prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity comp... Comment on Clin Cancer Res. 2001 Sep;7(9):2832-9. F Innocenti,MJ Ratain...
Impaired 5FU degradation, through low DPD activity, has led to severe, life-threatening or fatal toxicity after administration of 5FU. Complete DPD deficiency is associated with the inherited metabolic disease thymine uraciluria. Several mutations in the gene encoding DPD have recently been identified...
水平较低,而其他对5-FU不敏感的细胞株则无此现象。结论:TS及DPDmRNA水平对应用5-氟脲嘧啶治 疗胃肠癌的疗效具有一定预测价值。 关键词结直肠癌胃癌5-氟脲嘧啶二氢嘧啶脱氢酶(DPD)胸苷酸合成酶(Ts) ValueofPredictionof5FUTreatmentEfficacywithDetermination ...
DPYD基因编码的二氢嘧啶脱氢酶(dihydropyrimidine dehydrogenase,DPD)是5-FU代谢的关键酶[3],可将进入体内约85%的5-FU分解为无活性的二氢氟尿嘧啶。DPD蛋白与5-FU的疗效密切相关,其异常表达可使结肠癌细胞获得耐药性[4]。因此,降低DPD的...