Bendectin was a combination of doxylamine 10 mg and pyridoxine 10 mg. Extensive review of safety data has revealed no adverse pregnancy outcomes from this combination or from doxylamine alone.10,34 Other drugs in this group, which all have shown efficacy and safety for controlling nausea and ...
当妊娠期剧烈恶心和呕吐症状出现时,多西拉敏(Doxylamine)Bonjesta的初始用法和剂量应根据医生的指导进行。一般而言,推荐的初始用量为每晚服用1片(10 mg唑来丁辛片(doxylamine)和10 mg吡坦唑嗪缓释片(pyridoxine)组合在一起),在晚上入睡前或睡前1小时服用。 2. 调整用量 (Adjustment) 针对个体差异以及患者症状的严重...
Doxylamine and pyridoxine dosing informationUsual Adult Dose for Nausea/Vomiting: Doxylamine 10 mg-pyridoxine 10 mg delayed-release tablets:-Initial dose: 2 tablets orally once a day at bedtime-Maintenance dose: 2 tablets orally once a day to 4 tablets orally 3 times a day-Maximum dose: 4 ...
Doxylamine succinate and pyridoxine hydrochloride delayed-release tablets (N = 133) Placebo (n = 128) Somnolence 19 (14.3%) 15 (11.7%) 6.2 Postmarketing Experience The following adverse events, listed alphabetically, have been identified during post-approval use of the combination of 10 mg doxy...
Toxicity data:LD50in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner) Derivative Type:Combination with pyridoxine hydrochloride Trademarks:Bendectin (Duchesnay); Diclectin (Duchesnay) ...
doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sic...
In April 2013 the FDA approved the delayed release combination of doxylamine succinate and -pyridoxine hydrochloride (Diclegis®) for NVP, following a phase 3 randomized trial in pregnant women. The fetal safety of this medication has been proven by numerous studies. However, because it is the ...
DICLEGISdelayed-release tablets are white, round, film coated tablets containing 10 mg doxylamine succinate and 10 mg pyridoxine hydrochloride. The tablets are imprinted with the pink image of a pregnant woman on one side. DICLEGISdelayed-release tablets are supplied in a high-density polyethylene bo...
doxylamine/pyridoxine/dicyclomine, doxylamine/pyridoxine, dicyclomine/pyridoxine, dicyclomine/doxylamine, doxylamine alone, pyridoxine alone, dicyclomine alone, or placebo. Each combination contained 10mg of each specified medication. Patients were directed to take two tablets at bedtime, and if needed, one...
doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sic...