1. 对照组1:感染对照序列shRNA + 给药dox 实验设计:使用无靶向性的随机序列或靶向无关基因的shRNA,其他条件与实验组完全一致(包括dox处理)。 作用: ① 排除dox本身的影响(例如药物毒性、非特异性效应); ② 排除shRNA非特异性干扰(例如载体或随机序列的脱靶效应)。 适用场景: 当需要明确表型变化是否由目的基因...
MMP-9 shRNA plasmidIt is a promising way to treat the multi drug resistance (MDR) of tumor cells in both of drug and gene methods. A polyamidoamne dendrimer functionalized graphene oxide (GO-PAMAM) was designed, which could load doxorubicin (DOX) and MMP-9 shRNA plasmid at the same ...
Graphene oxide Dendrimer DOX MMP-9 shRNA plasmid Co-delivery 1. Introduction One single drug treatment is increasingly difficult in the field of cancer treatment, it is mainly because the multi drug resistance (MDR) of tumor cells caused a huge obstacle [1], [2], [3]. Although people cons...
Decrease of ATR level by shRNA had no effect on DOX-induced ERK1/2 activation.Ryan, H. KolbPatrick, M. GreerPhu, T. CaoKenneth, H. CowanYing, Yan
Multifunctional Fe 3 O 4 [emailprotected] 2 (Ce6/Dox)-PEM/P-gp shRNA nanocomplexes as theranostic agent for cancer dual-modal imaging and chemo-photodynamic therapydoi:10.1016/j.jconrel.2017.03.112SDOSJournal of Controlled Release