S5A-B). Conversely, inhibition of EIF5A hypusination by GC-7 or DFMO did not affect ERK or AKT activity (Figs. S5C-D). These results place polyamine biosynthesis and EIF5A hypusination downstream of ERK and AKT signaling in vemurafenib resistance. Previous study identified c-Myc as ...
(b) When k is large or \(\gamma\) is large (i.e., \(k>1/(4\gamma )\) or \(1/(4\gamma ) \le {k}_{0}\)), because upstream R&D is inefficient or the downstream market is competitive, the effects of upstream investment on the input price weaken, and the effect of horizont...
This effect was not observed with the alpha I allosteric inhibitor LFA878 or the anti-alpha L beta 2 mAb efalizumab. On the other hand, efalizumab triggered the unscheduled internalization of alpha L beta 2 in CD4+ and CD8+ T cells while LFA878 and XVA143 did not affect or only mildly ...
(2) The disclosure, regardless of when presented, had no effect on participants behavior in a subsequent non-nudged choice. Additionally, the disclosure did not affect the nudges influence on the initial choice. We conclude that lack of transparency can hurt choice architects reputation and discuss...
Refer to Figure 2 as example, when bypass at hot side of HX3 is changed, there are two downstream paths to affect y1 dotted curves illustrating. Sign in to download hi-res image Figure 2. Example of two downstream paths with opposite effect Path 1: 3H->4H->4C->2C->y1, (4), + ...
beta1C inhibitory effect on cell proliferation is completely prevented by p27(kip1) antisense, but not mismatch oligonucleotides. beta1C expression does not affect either cyclin A or E levels, or cyclin E-associated kinase activity, nor the mitogen-activated protein (MAP) kinase pathway. The...
may affect irrigation in both upstream and downstream areas. wrdmap.org 同时跨行业调水使问题进一 步复杂化,上游灌溉转用下游城市 用水 会对 上 游 和下 游地 区灌 溉都造成影响。 wrdmap.org [...] sanctions, all relevant individuals and entities both upstream and downstream of mineral sup...
Increasing complexity and accountability in today's health care environment has added additional pressures to physician practice further perpetuating high levels of stress and burnout that can adversely affect both physical and emotional behaviors. And more disturbingly it can adversely impact patient ...
and the separation point was not right at the corner tip but at some lover point of the upper corner. The results revealed that the periodically heated wall has no effect on the flow field. In this study, and the oscillatory wall temperature did not affect the distribution of isotherms for...
Droughts are complex natural hazards that, to a varying degree, affect some parts of the world every year. The range of drought impacts is related to droug... Motalleb,Byzedi,Bahram,... - 《Environmental Earth Sciences》 被引量: 20发表: 2013年 Impact of land-use, climate change and gro...