RESEARCHDOWN syndromeResearch in the field of Down syndrome is under threat. There are two issues behind this threat: first availability of research funding could be limited by the perception that Down syndrome has become a rare condition. The second is that some believe the important work on ...
The 3-year study, called the Down Syndrome Biomarker Initiative (DSBI), involved twelve participants between the ages of 30 and 60 with Down syndrome, to study their aging process. The study focused on how soon protein plaques developed, where in the brain they were located and the effects ...
Where one parent has Down's syndrome, there is a 35% to 50% chance that the child would inherit the syndrome. This chance is even higher where both parents have Down's syndrome. There is also a high chance that pregnancy would end inmiscarriage. Women with Down's syndrome are also more...
Contrary to common expectation, the prevalence of Down syndrome (DS) is increasing. The effect of antenatal diagnosis, and the ensuing termination of many affected pregnancies, is being outweighed by the effects of childbearing later in life and the increased longevity of individuals with DS.1 ...
open new perspectives for research, since the methodology can be applied to other genetic diseases. "We now need to find which of the deregulated proteins are responsible for each particular symptom of Down's syndrome. Then we need to see if new discoveries are possible for other types of cel...
Down's syndrome, also known as trisomy 21, is one of the most common genetic diseases. Researchers from the University of Geneva (UNIGE) and ETH Zurich (ETHZ), Switzerland, have recently analysed the proteins of individuals with trisomy 21 for the first time: the goal was to improve our ...
Virtually all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by the age of 40 years. This association is partially due to overexpression of amyloid precursor protein, encoded by APP, as a result of the locatio
Carol Boys, chief executive of the Down Syndrome Association, said, "We have known for a long time that people who have Down syndrome experience an aging process which appears faster than in the general population. To have a landmark research study like this, published by highly respected rese...
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Original research: Rates, causes, place and predictors of mortality in adults with intellectual disabilities with and without Down syndrome: cohort study w... To investigate mortality in adults with intellectual disabilities: rates, causes, place, demographic and clinical predictors....