A study that revealed the sequence and gene catalogue of the long arm of chromosome 21, which were crucial findings for Down syndrome research. Article CAS PubMed Google Scholar Lott, I. T. Neurological phenotypes for Down syndrome across the life span. Prog. Brain Res. 197, 101–121 (...
In this article Dr Gaad, Assistant Professor in the Department of Special Education at the University of the United Arab Emirates, reports on her Government-funded research into the education of children with Down's syndrome in her country. As an Arabic speaker, Dr Gaad was able to gather ...
Cite this article Lott, I.T., Head, E. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol 15, 135–147 (2019). https://doi.org/10.1038/s41582-018-0132-6 Download citation Published07 February 2019 Issue DateMarch 2019 DOIhttps://doi.org/10.1038/s4...
Cite this article Lott, I.T., Head, E. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol 15, 135–147 (2019). https://doi.org/10.1038/s41582-018-0132-6 Download citation Published07 February 2019 Issue DateMarch 2019 DOIhttps://doi.org/10.1038/s4...
“The idea of shutting off a whole chromosome is extremely interesting” in Down’s syndrome research, says stem-cell researcher Nissim Benvenisty of Hebrew University in Jerusalem. He anticipates future studies that split altered cells into two batches — one with the extra chromosome 21 turned...
We previously obtained evidence for reduced cell proliferation in the dentate gyrus (DG) of fetuses with Down syndrome (DS), suggesting that the hippocampal hypoplasia seen in adulthood may be caused by defective early neuron production. The goal of this study was to establish whether DS fetuses ...
The article presents a summary of the study "A summary of recent research into the development of children with Down's syndrome," by X. Y. Hartley, which originally appeared in the "Journal of Mental Deficiency Research" in 1986. The methods, results and conclusions of the study are briefly...
open new perspectives for research, since the methodology can be applied to other genetic diseases. "We now need to find which of the deregulated proteins are responsible for each particular symptom of Down's syndrome. Then we need to see if new discoveries are possible for other types of cel...
Down syndrome (DS; Trisomy 21) is the most common chromosomal disorder in humans. It has numerous associated neurologic phenotypes including intellectual disability, sleep apnea, seizures, behavioral problems, and dementia. With improved access to medical care, people with DS are living longer than ...
More than five million Americans are living with Alzheimer's disease (AD). Of them, 400,000 also have Down syndrome. Both groups have similar looking brains with higher levels of the protein beta amyloid. In fact, patients with Down syndrome develop the