Here, we analyzed the distribution, morphology, and dendritic complexity (Neurolucida reconstructions) of NO-producing neurons through NADPH diaphorase (NADPHd) activity, and how they compare with the distribution of doublecortin-positive (DCX+) neurons in the hippocampal formation of the neotropical ...
DCX/Doublecortin 抗体产品应用WB 成分亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,叠氮化钠<0.02% 保存条件-20℃保存 背景资料The DCX/Doublecortin is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must ...
In our iPSC models, DCX-KO neurons showed impaired nucleokinesis and increased neurite branching, consistent with phenotypes inDcx-/yrodent studies51,52. Using our DCX-KO model, we find that excessive branching is the result of higher rates of branch initiation, a pathway known to involve sever...
Doublecortin (DCX) is a microtubule (MT)-stabilizing protein essential for neuronal migration during human brain development. Missense mutations in DCX cause severe brain defects. This implies that the many other MT-stabilizing proteins in neurons cannot compensate for DCX function. To understand the ...
Keywords: Doublecortin, Temporal lobe epilepsy, Hippocampus, Memory, Microglia Introduction Doublecortin (DCX) is a microtubule-associated protein critical for normal neuronal migration during develop- ment. It has been widely used as a reliable marker to study post-mitotic, immature neurons in the ...
Doublecortin (DCX) as a case study has never been reported to traffic the nuclear membrane. DCX is crucial for neuronal migration and differentiation of human neurons, and it is a reliable marker of adult neurogenesis due to its pivotal roles in neuroblast formation [8]. DCX is expressed in ...
Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins after 2 ...
Nuclear translocation of several oncogenic proteins have previously been reported, but neither the translocation of doublecortin (DCX) nor the mechanism involved has been studied. DCX is a neuronal microtubule-associated protein (MAP) that is crucial for adult neurogenesis and neuronal migration and has...
It is believed that the population of homozygous mutant cells form the subcortical band of neurons. DCX encodes a 40 kDa cytoplasmic protein consisting of 360 amino acids. N-terminally, DCX contains two repeats that bind to microtubules. DCX is thus a microtubule-associated protein (MAP) that ...
Humans with mutations show profound alterations in cortical lamination, whereas in mouse, RNAi-mediated knockdown but not germline knockout shows abnormal positioning of cortical neurons. Here, we report that the doublecortin-like kinase (Dclk) gene functions in a partially redundant pathway with Dcx ...