It is anticipated that the first futility analysis (for harm) will take place after 25% of events have been observed, followed by a futility analysis after 46% of events of observed (t0 from Frei- dlin's paper
{1/2}} at n_{\sigma } (we use hatted quantities to indicate sensitivities instead of true values), defined as the half-life corresponding to the signal that could be emulated by a background fluctuation of a chosen significance level, expressed in numbers of Gaussian standard deviations (n...
Affected by Double Turbulence Sources Xinghua Li1, Jianen Gao1,2,3,4 ✉, Zihao Guo3,Yan Yin2, Xingchen Zhang3, Pengcheng Sun2 & Zhe Gao1 To increase the available land area, a large-scale land remediation campaign was carried out in the loess hilly and gully area....
But perhaps of equal significance is that Japan – like the US – faced what I called both a demand-side and a supply-side problem. Japan focused solely on demand-side solutions, not on supply-side solutions. Yet demand- and supply-side problems required both demand- and supply-side ...
No other difference in event rates between nOPV2 and bOPV within the age cohorts was significant at the 5% significance level. 98 (33%) of 300 (95% CI 27–38) young children had a solicited adverse event following a first or second dose of both nOPV2 and bOPV (table 4). There were...
We will test for main effects of CT and PRT, as well as for the interaction term (CT × PRT) to identify isolated and combined training arm significance and effects sizes. Relationships of interest and risk factors for changes in cognitive function and other secondary outcomes will be analysed...
significance for the QIDS-SR may be due to the fact that, unlike the SDQ and CPFQ, the QIDS-SR was only administered at baseline and endpoint for each stage (making an MMRM analysis impossible). Based on these findings, the results of the present study are consistent with those reported ...
To detect a non-inferiority margin of 10% in seroconversion 28 days after vaccination, with a 2·5% significance level for a one-sided test, 90% power, and accounting for 5% loss to follow-up and 15% baseline yellow fever seropositivity (ie, PRNT50 titre ≥10), a sample size of 120...
The decision means scientists have too little time to study bones and other human remains of national and cultural significance.“Your current requirement that all archaeologically unearthed human remains should be reburied, whether after a standard period of two years or further special extension, ...
Although…I could see them calling it theObama Institute for Campaign Ethics Reform. Let’s look at the Iranian/Saudi war that’s been raging across the Middle East for the last….. what? 8-12 centuries? Sure, it gets “Hot” and “Cold”, but the last few years, with Obama choosing...