Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3′ of uridine (U). While prior structural data shows that to cleave double stranded RNA,
Donkey wish your girlfriend was Kong like me? Having stunned audiences with Donkey Kong Country 2: Diddy’s Kong Quest, Rare had an awful lot to live up to on the final entry of the original Donkey Kong Country trilogy. Donkey Kong Country 3: Dixie Kong’s Double Trouble! sees the titu...
The precise repair choreography remains unknown but linear HIV-1 pre-integration complexes with plus-strand discontinuities are competent to integrate in vitro (Miller et al., 1995), suggesting that in the bona fide provirus the repair can occur after ligation of the LTR 5′ termini to host ...
Keywords: DNA repair; long non-coding RNA; microRNA; DNA damage; double-strand breaks; NHEJ; HR 1. Introduction One of the most remarkable advances in molecular biology during the last decade is the annotation of the transcriptome in numerous organisms and the discovery that ~75% of the ...