beagle,又称(小)猎兔犬,音译为米格鲁、比格犬,小型至中型的狩猎犬种 dose-range-finding,简称DRF,剂量范围研究 供参结果一 题目 英语翻译dose-range-finding study in beagle dogs following oral administration.这个是实验目的,是整句了, 答案 Dose-range-finding Study in Beagle Dogs Following Oral Administration...
Dose-range-finding Study in Beagle Dogs Following Oral Administration 意译:小猎兔犬口服给药的剂量范围研究(DRF)试验 音译:比格犬口服给药的剂量范围研究试验 beagle,又称(小)猎兔犬,音译为米格鲁、比格犬,小型至中型的狩猎犬种 dose-range-finding,简称DRF,剂量范围研究 供参 解析看不懂?免费查看同类题视频解...
Early repeated dose-range finding (DRF) toxicology studies, usually conducted in rodent and non-rodent animal species, seek to provide the earliest assessment of the toxicity profile of new chemical entities (NCE) using well-designed and validated nonclinical study designs. Thus, the DRF study ...
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Recommended nonclinical safety studies include a 3-month Good Laboratory Practice (GLP) dose-range finding (DRF) study prior to conducting the 2-year dermal carcinogenicity study in rats. Demonstration of systemic exposure is necessary to interpret the in vivo data. Previous nonclinical reports ...
The 4-week repeated-dose toxicity study is usually conducted as a ‘follow-on’ study after the acute (single-dose) and 1-to 2-week (dose range-finding) studies have been conducted. Thus, the 4-week study is conducted to strengthen the toxicity data for the potential pharmaceutical product...
At this stage, first, fit for purpose in vivo studies are conducted to address early target or chemistry-related safety concerns. The first general toxicology studies aremaximal tolerated dose(MTD) and dose-range finding (DRF) studies generally performed in rodents and nonrodents. The value of ...
Toxicological assessments were performed in a single-dose toxicity study by intravaginal administration with local tolerance study, 1-week repeated-dose intravaginal toxicity dose range finding (DRF) study, and a 2-week repeated-dose intravaginal toxicity study with a 2-week recovery period. Studies ...
acute toxicity testingpilot toxicity testingdrug safety evaluationrange-finding studiesdose probesSummary This chapter contains sections titled: Introduction Range-Finding Studies Acute Systemic Toxicity Characterization Screens Pilot and DRF StudiesShayne Cox Gad...
When coffee consumption was illustrated by ranges of intake, the midpoint of the range was used. When the highest category was open-ended, we assumed that the width of the upper category was the same as the adjacent category. When the lowest category was open-ended, we set the lower ...