VITAMIN B12 deficiencyTYPE 2 diabetesPERIPHERAL neuropathyMETFORMINTREATMENT durationAims: To evaluate the prevalence of vitamin B12 deficiency in Chinese patients with type 2 diabetes mellitus receiving metformin treatment and to investigate the effects of metformin daily dose and treatment duration on the ...
Among patients with BMI of at least 16, we found no effect of high-dose multivitamin supplementation compared with standard-dose supplementation on the risk of death (11.6% vs 11.8%; RR, 0.98; 95% CI, 0.81-1.19; P = .88). Among patients with BMI of less than 16 at baseline, for ...
Aflibercept was administered over 1 h, followed in sequence by fixed doses of pemetrexed (500 mg m2 i.v. over 10 min) and cisplatin (75 mg m2 i.v. administered as per institu- tional practice; typically 2 h). Patients were supplemented with vitamin B12 (1000 mcg intramuscularly) 1 ...
peripheral neuropathyObjective No clinically effective treatment for promoting peripheral axonal regeneration has yet been established. Several experimental studies in vitro and in vivo have shown that a high dose of methylcobalamin (MeCbl), an analogue of vitamin B12, promotes axonal growth in ...
vitamin B12neurological deficitslaughing gasBackground: Nitrous oxide (N2O) has been used in clinical and recreational settings for over 150 years. Through inactivation of the Vitamin B12 dependent enzyme, methionine synthase, N2O can lead to the development of peripheral neuropathy. This study sought...
Vitamin B6Background: Peripheral neuropathy is a commonlyencountered troublesome condition which is often disabling & worsens whenleft untreated. Traditional neuropathic pain medications primarily providesymptomatic relief; however, the pathogenesis of nerve damage remainsunresolved. Extensive literature survey ...
Post-marketing surveillance of fixed dose combination of methylcobalamin, alpha lipoic acid, folic acid, biotin, benfotiamine & vitamin b6-nutripathy for the management of peripheral neuropathy. J Diab Mel 2014 May;4(2):124-132.Maladkar M, Tekchandani C, Dave U (2014) Post-marketing ...
This includes most of the B vitamins, with the notable exception of vitamin B12, which is particularly abundant in red meat [29,30]. 2. Mechanisms of Action and Functions of B Vitamins B vitamins act as coenzymes in a substantial proportion of the enzymatic processes that underpin every ...
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