We investigated the effects of antioxidant N-acetylcysteine (NAC) on TNF-induced human umbilical vein endothelial cells (HUVECs) apoptosis and the production of NO and antioxidant enzymes. METHODS Cultured HUVECs (cell line ECV304) were either not treated (control), or treated with TNFalpha (40...
Prophylactic administration of N-acetylcysteine (NAC) (600mg orally twice daily), along with hydration, prevents contrast agent-associated nephrotoxicity (CAN) induced by a low dose of non-ionic, low-osmolality contrast dye. We tested whether a double dose of NAC is more effective to prevent CAN...
Low-dose Intravenous N-acetylcysteine for the Prevention of Contrast-Induced Nephropathy in Emergency Patients Undergoing Computed Tomography Purpose: To evaluate the effects of low-dose intravenous N-acetylcysteine on the prevention of contrast-induced nephropathy (CIN) in patients undergoing computed tomog...
Patients undergoing primary angioplasty were randomized to either high-dose N-acetylcysteine (2 × 1,200 mg/day for 48 h; n = 126) or placebo plus optimal hydration (n = 125). The 2 primary end points were: 1) the occurrence of >25% increase in serum creatinine level <72 h after ra...
Comment on “What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?” by Hendrickson et al.Comment on “What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?” by Hendrickson et al.doi:10.1080/15563650.2019.1594873D...
The objective of this study is to determine the effect of intravenous (i.v.) or oral N-acetylcysteine (NAC) in preventing contrast-induced nephropathy (CIN) in patients with moderate-to-severe renal insufficiency undergoing intra-arterial interventions.We studied 307 patients with estimated glomerular...
acetylcysteinehepatotoxicityMethods The use of N-acetylcysteine (NAC) remains the standard of care for treatment of acetaminophen (APAP) toxicity and overdose. Currently, there is growing evidence to suggest that massive acetaminophen overdose is associated with increased hepatotoxicity despite timely ...
N-acetyl cysteineAnalgesic effectHot plateCo-administrationPainRatCo-administration of NAC with APAP can improve the antinociceptive effect of APAP. It is suggested that this compound can enhance analgesic effects of APAP and eventually lead to a reduction in acetaminophen dose. Further studies are ...
investigated the efficacy of combined N-acetylcysteine (NAC) and low-dose estrogen treatment against cardiometabolic dysfunction in female estrogen-deprived obese rats with cardiac ischemia-reperfusion (I/R) injury.#Bilateral ovariectomized (O) female Wistar rats were fed a high-fat diet (H) for 12...
ACETYLCYSTEINEPEOPLE with diabetesWOUND healingCOLLAGENSUPEROXIDE dismutaseOxidative stress and persistent inflammation play crucial role in the progression of diabetic wound complications. N-Acetylcysteine (NAC) is an amino acid derivative that promotes wound healing because of its ability of ant...