In addition, as outcome-adaptive dose finding methods often involve complex algorithms, it is crucial to have diagnostic tools to evaluate the plausibility of a method's simulated performance and the adequacy of the algorithm. In this article, we propose a simple technique that provides an upper ...
To determine the volume recombination at high dose-per-pulse in liquid ionization chambers (LIC) and to ascertain whether existing calculation methods verified in air-filled chambers may be used to calculate a correction factor.Two LICs, one filled with 2,2,4-trimethylpentane (isooctane) the ...
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of course, have to be a noisy image, but if any feature caught the eye, it could be run over again with the CT brush set to a higher intensity. A suspect region would then be sharpened up
The radiation source is allowed to dwell in the target areasuntil the prescribed radiation dose is reached and is then removed with the goal of increasing direct tumor necrosis and reducing toxicity and surrounding tissuedamage.Policy Number
Yeh KC, Chremos AN, Lin JH, et al. Single-dose pharmacoki- netics and bioavailability of famotidine in man: results of multicenter collaborative studies. Biopharm Drug Dispos 1987; 8: 549-60.Yeh KC, Chremos AN, Lin I, et al: Single-dose pharmacokinetics and bioavailability of famotidine ...
Calcineurin is a Ca2+ヾependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activation increases the expression of proliferator゛ctivated receptorゞamma ...
The treatment parameters were used to model the optimum treatment assembly, such as different thickness of reflectors and beam orientations. The Figure of merits (FOMs) such as total treatment time, total maximum skin dose and synovium to bone treatment ratio were used to evaluate the effect of...
dose‐finding methods in delayed toxicity outcomesdose‐finding with delayed binary outcomesTITE〤RMIntensity modulated radiation therapy (IMRT)simulationIMRT scenarioscorrect weight functionchronic toxicity formulationtime‐to〆vent approach and likelihood‐based dose‐finding methods...
Agrawal NG, Porras AG, Matthews CZ, Rose MJ, Woolf EJ, Musser BJ, Dynder AL, Mazina KE, Lasseter KC, Hunt TL, Schwartz JI, McCrea JB, Gottesdiener KM. Single- and multiple-dose phar- macokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, in man. Journal of Clinical ...