A good dose-escalation design is anticipated to yield high accuracy of selecting the correct dose while using fewer patients and keeping the trial duration short. Recently, treating a single patient at each lower dose level until certain events are triggered to switch to larger cohorts has gained...
Throughout the course of the dose escalation trial no patient experienced a DLT and thus MTD was not achieved. Because no MTD was reached, the recommended phase 2 dose (RP2D) was determined based on the pharmacokinetic (PK) profile. Table4shows the PK parameters for VT1021 by dose cohort ...
et al. Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial. Nat Med 28, 1022–1030 (2022). https://doi.org/10.1038/s41591-022-01762-x Download citation Received30 June 2021 Accepted28 February 2022 ...
Getting to know these new meds can greatly improve your care of ocular disease patients. Two Future Therapies Bausch + Lomb, with partner Novaliq, announced top-line results from the first Phase III trial of NOV03. This perfluorohexyloctane agent works to solubilize lipids for the treatment ...
BioEclipse Therapeutics™ announced the initiation of patient enrollment in a Phase 1 dose-escalation trial to treat refractory solid tumors. The trial marks the first-in-human study of CRX100, an intravenously-delivered cancer therapy designed to target and...
学术范收录的Journal Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy,目前已有全文资源,进入学术范阅读全文,查看参考文献与引证文献,参与文献内容讨论。学术范是一个在线学术交流社区,收录论文、作者、研究机构等信
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13(8):782–9. 25. Subbiah V, Kreitman RJ, Wainberg ZA, Cho JY, Schellens JHM, Soria JC, et al. Dabrafenib and trametinib treatment in patients with ...
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13(8):782–9. 25. Subbiah V, Kreitman RJ, Wainberg ZA, Cho JY, Schellens JHM, Soria JC, et al. Dabrafenib and trametinib treatment in patients with ...
A single arm, multi-center, phase II, dose escalation prospective clinical trial employing the i3 + 3 design is being conducted to examine the safety of a radiation dose-escalation strategy aimed at inducing transmural scar formation. The ultimate objective of this trial is to decrease the ...
The first patient was dosed in June 2022. The Phase I dose escalation trial of the IMM27M for solid tumors is progressing smoothly. Overall data showed that IMM27M was well tolerated, without dose-limiting toxicities (DLTs) occurring in all subjects across the seven dose groups of 0.1 mg/...