US4913906 1986年2月24日 1990年4月3日 Bialer; Meir Novel controlled release dosage form of valproic acidUS4913906 Feb 24, 1986 Apr 3, 1990 Michael Friedman Drug delivery; uniform mixture with polymer; also salts, amides, estersUS4913906 * 1986年2月24日 1990年4月3日 Michael Friedman Novel ...
Valproic acid is a carboxylic acid designated as 2–propylpentanoic acid. It is also known as dipropylacetic acid. Valproic acid (pKa 4.8) has a molecular weight of 144 and occurs as a colorless liquid with a characteristic odor. It is slightly soluble in water (1.3 mg/ml) and very solu...
Lamictal may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Tell your doctor if you have ever had: ...
KEPPRA injection is for intravenous use only and should be diluted in 100 mL of a compatible diluent prior to administration. If a smaller volume is required (e.g. pediatric patients), the amount of diluent should be calculated to not exceed a maximum levetiracetam concentration of 15 mg per ...
Hepatotoxicity induced by valproic acid overdose: IV loading dose of L-carnitine 100 mg/kg; a maintenance dose of 50 mg/kg (to a maximum of 3 g/dose) administered every 8 hours may be used. Infertility, male: Carnitine 2 g/day, L-carnitine 2 to 3 g/day, acetyl-L-carnitine 0.5 to...
of surfactant, if needed (e.g., dissolution of valproic acid capsules, methoxsalen capsules). If the liquid-filled capsule contains a water soluble active substance, then the addition of a surfactant is generally not needed; however, this is a function of...
A simple, accurate and reproducible HPLC method is described for the assay of valproic acid and its sodium salts in commercial dosage forms. The analyte and sodium caproate, the internal standard, were detected in the UV range after formation of the corresponding phenacyl ester derivatives with a...
Gingko biloba is an herb that promotes blood circulation and may help improve memory. Gingko may interfere with drugs prescribed to treat a variety of health conditions. High doses of the herb may make antiseizure medications like carbamazepine (Carbatrol, Equetro, Tegretol) and valproic acid (De...
Isoniazid has been reported to inhibit the metabolism of the following drugs: anticonvulsants (e.g., carbamazepine, phenytoin, primidone, valproic acid), benzodiazepines (e.g., diazepam), haloperidol, ketoconazole, theophylline, and warfarin. Therefore, isoniazid may increase the risk of toxicities ...
23. The process according to claim 20 in which said aqueous solution is a 0.0001-0.1 normal solution of a food grade acid. Description: The present invention is directed to new solid dosage forms of divalproex sodium, valproic acid, prodrugs of valproic acid, and analogs of valproic acid (he...