Dopaminergic synapse pathwayMAPK pathwayMutant huntingtinHuntington disease (HD) is the most common neurogenetic disorder caused by expansion of the CAG repeat in the HTT gene; nevertheless, the molecular bases of the disease are not fully understood. Non-coding RNAs have demonstrated to be involved...
Amphetaminesincrease synaptic DA by causing its release into the synapse and both amphetamines and cocaine potently inhibit the DA reuptake transporter. View chapter Book 2012,Core Psychiatry (Third Edition) PádraigWright,Michael F.O'Neill Review article ...
Dopamine levels within the synaptic cleft reach considerably high concentrations (estimated to be in the hundreds of micromolar range [43]), which should saturate postsynaptic D2 receptors that are preferentially localized within the synapse [44]. Most of the released dopamine is then rapidly removed...
“serotonin receptor signaling pathway” (GO:0007210), “serotonin transport” (GO:0006837), “serotonin metabolic process” (GO:0042428) and “serotonin production involved in inflammatory response” (GO:0002351). For the exploration of KEGG pathways (https://www.genome.jp/kegg/pathway...
using the terms "dopamine" or "serotonin" as keywords, and only those pathways more tightly related to neurotrans- mitters' function were kept: "dopaminergic synapse" (hsa04728) and "tyrosine metabolism" (hsa00350), and "serotonergic synapse" (hsa04726) and "tryptophan metabolism" (hsa00380)...
Increased DAT phosphorylation leads to increased cocaine affinity for DAT to increase dopamine leavels in synapse Cocaine Dopamine VTA dopamine terminals in NAc Male Oestrus Dioestrus Activity-dependent changes in dopamine transporter function during oestrus leads to increased cocaine conditioned place ...
[25]The subset of ventral tegmental area projection neurons that synapse onto the D1-type medium spiny neurons in the shell appear to be responsible for immediate drug reward(i.e., "wanting").[3][26][27]Addictive drugs have a larger effect on dopamine release in the shell than in the ...
elegans dopaminergic synapse {modified from [8]}. Release of dopamine can activate auto- receptor function of DOP-2 to initiate signal transduction through GPA-14 ([21], and this report). In parallel, the accompanying drop in synaptic pH due to the release of H+ ions from the acidified ...
(STR) form the nigrostriatal pathway that is important for controlling voluntary movement. Projections from VTA to the nucleus accumbens (NAc) and the frontal cortex make up the mesocorticolimbic pathway to regulate memory, reward, motivation and emotion [4]. Similar to ADHD [5], bipolar ...
C. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum. Elife 9, e54443 (2020). Article CAS PubMed PubMed Central Google Scholar Boele, H. J., Koekkoek, S. K., De & Zeeuw, C. I. Cerebellar and extracerebellar involvement in...