As aminopterin blocks endogenous pathways required for purine and pyrimidine synthesis, the parent N18TG2 cells, which cannot utilize hypoxanthine, do not survive in this medium. Hybrid cells resulting from the fusion of N18TG2 and primary corpus striatum cells have the HPRT defect corrected by ...
Several works have demonstrated, in AD patients and animal models, that noradrenergic and dopaminergic neu- rotransmission pathways innervating the hippocampus and the cortical brain areas are extensively affected by AD pro- gression (Moreno-Castilla et al. 2016; Martorana and Koch 2014; Nobili et...
38, 39 As a result, it has long been suspected that the efficacy of levodopa in most patients with PD depends in part on surviving striatal 5-HT pathways originating from the raphe nuclei, which also contain AADC needed for the synthesis of 5-HT. Because there was less degeneration in ...
Calcium directly binds transcription factors such as DREAM (Carrion et al., 1999) and activates the nuclear CaM kinase pathways that modulate gene expression. (Chawla, 2002). We have observed that activation of nuclear AT1 receptors increases nuclear Ca2+ levels, and that inhibition of IP3 ...
Dopaminergic Pathways in Obesity-Associated Inflammation. J. Neuroimmune Pharmacol. 2020, 15, 93–113. [CrossRef] 11. Li, M.; Zhou, L.; Sun, X.; Yang, Y.; Zhang, C.; Wang, T.; Fu, F. Dopamine, a co-regulatory component, bridges the central nervous system and the immune system....
As already mentioned, in spite of the co-variation of voltage dependences of IA and IH currents [21], Kv4.3 and HCN channels were not found to interact at the molecular level, meaning that co-regulation by the same signaling pathways may not imply a strict nanometric co-localization of ...