(A) Location of the main dopaminergic mesencephalic structures in the adult mouse brain (sagittal view). Substantia nigra (SNc, in violet) dopaminergic neurons project to the dorsal striatum containing the caudate nucleus and the putamen. Dopaminergic neurons from the ventral tegmental area (VTA, ...
Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location?APOPTOSIS-INDUCING FACTOROXIDATIVE STRESSCELL-DEATHDNASEMITOCHONDRIAINVOLVEMENTMECHANISMSParkinson's disease (PD) is characterised by the loss of dopaminergic neurons in the substantia nigra and accumulation of pathological...
Centraldopaminergic neuronscomprise the incertohypothalamic system that connects themedial preoptic area(MPOA) and the paraventricular nucleus (PVN) to the lumbosacral spinal cord[6].Dopaminergic receptors, D1-like (D1and D5) and D2-like (D2, D3and D4), are postulated to regulate the central...
Loss of TH+ neurons and fibers in the VM of Top IIβ null mice. TH-immunostaining was performed in sagittal sections of E18.5 Top IIβ+/+ and Top IIβ-/- mice brains. The location of TH+ neurons areas were indicated by horizontal arrows (SNc) and arrowheads (VTA). Vertical arrowheads...
neurons are added to ascending dopaminergic populations throughout adult life, but there is evidence that mammalian adult DA neuronal generation can be triggered through stimulation20,21,22. A key unanswered question is whether ascending adult DA neurons or other neuronal populations that could play a...
(C) (Left) Expression of jRGECO and fiber location in SNc. Scale bar: 1 mm. (Right) A zoom in of the image shows jRGECO neurons in red. TH was used to delimit SNc area (blue). Optic fiber was located above the SNc. Scale bar: 250 µm. Extended Data Fig. 8 Post-hoc...
is the inner substructure of the nucleus accumbens.Location:The nucleus accumbens core is part of the ventral striatum, located within thebasal ganglia.Cell types:The core of the NAcc is made up mainly ofmedium spiny neuronscontaining mainly D1-type or D2-type dopamine receptors. The neurons ...
Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part from dysregulated activity of ventral tegmental area dopaminergic (THVTA) neurons, as well as from more global maladaptation in neurocircuit function. However, wh
Figure 1. The Majority of the Lamprey Dopaminergic SNc/VTA Neurons Co-express vGluT mRNA (A) Schematic dorsal view of the lamprey brain (top) showing the location of SNc/VTA and the level of transverse brain sections shown below and in Figures 1B and 1F. Schematic transverse brain section ...
VTA DA neurons are immunohistochemically identified by the presence of tyrosine hydroxylase (TH), a rate-limiting enzyme in the production of DA (Berger et al, 1982; Javoy- Agid et al, 1981a; Javoy-Agid et al, 1981b; Margolis et al, 2006b). The VTA is also comprised of local ...