The time point of drug admin- istration was based on pharmacokinetic data for both drugs (Coukell et al. 1996; Rosenzweig et al. 2002; Wright et al. 1997). Patients' eligibility to proceed with the scanning was as- sured by ECG monitoring. We initially administered a single oral dose ...
drugstemperamentThe risk factors for depressive symptoms in patients with Parkinson's disease (PD) under dopaminergic drug treatment are unclear. In this study, we examined whether some temperament traits are related to the presence of comorbid depression in PD patients, independent of the ...
Despite the intensive efforts in PD research and development, there are clear unmet medical needs for the development of additional dopaminergic treatment options to improve current DA-centered treatment. Most currently used dopaminergic drugs selectively activate D2-like DA receptors (Table1), but no ...
Restless legs syndrome treatment with dopaminergic drugs Sixteen patients with symptoms of restless legs syndrome and resulting insomnia are included in this study. They were nine women and seven men with a mean ... Akpinar,Levket - 《Clinical Neuropharmacology》 被引量: 206发表: 1987年 Static me...
As a consequence, patients under dopaminergic drugs, mainly dopamine agonists, can suffer from impulse control disorders (Sáez-Francàs et al., 2016). However, the interactions between these two dopaminergic pathways are not fully understood yet. Interestingly, SNc and VTA dopaminergic neurons share...
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All AP drugs are potent D2 receptor antagonists and many are also potent 5HT2A receptor antagonists. Improvements in positive and negative symptoms are thought to result from altered dopaminergic function in the limbic and prefrontal cortex, respectively. Tricyclic (TCA) antidepressant (AD) drugs inh...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook dopaminergic Medical Wikipedia do·pa·mi·ner·gic (dō′pə-mə-nûr′jĭk) adj. Of, relating to, or activated by dopamine or related substances. ...
THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks 1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and ...
Dr. Hauser and colleagues evaluated the safety and effectiveness of a range of doses of preladenant in 253 patients experiencing "wearing off" symptoms from their levodopa therapy. The patients were also receiving other available anti-parkinsonian drugs, such as dopamine agonists and/or entacapone...