Since these drugs were introduced in the 1950s, acute extrapyramidal syndromes have been associated with these neuroleptic agents. Indeed, the word "neuroleptic," meaning "to take the neuron," was intentionally created to encompass the concept that both antipsychotic benefits and motor side effects ...
MSCs were extracted from the bone-marrow of GFP transgenic rats, meaning grafts could be easily identified using fluorescent microscopy. The encapsulation of MSCs in hydrogels of increasing levels of 4s-StarPEG had no negative effect on graft volume in each group, at each time-point (B,C). ...
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse. Curr Top Behav Neurosci. 2010;3:29-71.PubMedGoogle Scholar 13. Kim E, Howes OD, Kapur S. Molecular imaging as a guide for the treatment of central nervous system disorders. Dialogues Clin Neurosci. ...
(C) Probability of escape evoked by 15 ms flash stimuli under the various treatments of dopaminergic signaling-relevant drugs. Apomorphine (“Apo”), non-selective dopamine receptor agonist; SCH-39166, D1R antagonist; quinpirole, D2R agonist; raclopride, D2R antagonist. (D) Effect of bilateral ...
All current antipsychotic drugs block dopamine (DA) receptors, but the nature of the DA dysfunction in schizophrenia has not been clear. However, consistent evidence now shows that presynaptic dopaminergic function is altered in schizophrenia, specifically in terms of increased DA synthesis capacity, ...
Concerning the animal models, interspecies differences are obstacles to the complete recapitulation of disease phenotypes, thus causing a high failure rate in the development of drugs. The use of primary cells is hampered by the impossibility of isolating viable neurons from adult brains.. On the ...
phenotypes, thus causing a high failure rate in the development of drugs. The use of primary cells is hampered by the impossibility of isolating viable neurons from adult brains.. On the other hand, even if cell lines generated from brain tumours can be easily cultured, their use is limited...