Dopaminergic DrugsDefinitionDefinitionMedications that either act as dopamine precursors (levodopa), dopamine mimickers (dopamine agonists), or dopamine level enhancers (monoamine oxidase-B inhibitors).DopamineMarc D. BinderNobutaka HirokawaUwe Windhorst...
Define dopaminergic. dopaminergic synonyms, dopaminergic pronunciation, dopaminergic translation, English dictionary definition of dopaminergic. adj. Of, relating to, or activated by dopamine or related substances. American Heritage® Dictionary of the
As a consequence, patients under dopaminergic drugs, mainly dopamine agonists, can suffer from impulse control disorders (Sáez-Francàs et al., 2016). However, the interactions between these two dopaminergic pathways are not fully understood yet. Interestingly, SNc and VTA dopaminergic neurons share...
Tricyclic (TCA) antidepressant (AD) drugs inhibit the reuptake of DA to the presynaptic neuron by the DA transporter while monoamine type A oxidase inhibitor (MAOI) AD drugs increase synaptic DA by inhibiting MAO, its catalytic enzyme. Amphetamines increase synaptic DA by causing its release into...
Using addictive drugs floods the limbic brain with dopamine, taking it up to as much as five or ten times the normal level. A person with elevated dopamine levels now has a brain that begins to associate the substance with an outside neurochemical reward (“Your Brain on Drugs”). As a ...
Drugs of abuse utilize the nucleus accumbens rewarding pathway and dopaminergic dysfunc- tion in the prefrontal cortex may underlie some forms of schizophrenia. Synonyms Ventral tegmental area Cross-References Definition ▶ Nucleus Accumbens ▶ Substantia Nigra ▶ Ventral Tegmental Area of Midbrain ...
The caudate is also particularly well placed to link evidence of the cholinergic system involvement in tremor with current models. Anticholinergic agents were the first drugs available for symptomatic treatment of PD – their original use dates to the time of Charcot53. Anticholinergic agents (trihexyp...
Drugs Unless otherwise specified, all chemicals were purchased from Sigma (St. Louis, MO). RIAs Mouse and rat serum prolactin were measured by RIA using kits provided by the National Institute of Diabetes and Digestive and Kidney Diseases [NIDDK; Dr. A.F. Parlow, National Hormone and Pituitary...
Thus, while the initial molecular binding site for various classes of addictive drug varies tremendously (see below), all drugs have been found to increase dopamine release. The significance of this common mechanism for the development of addiction is clearly seen when one considers that this is ...
In addition, drugs increasing dopamine signalling appear to have a favourable impact on motivational or psychomotor functions (Salamone et al., 2016a,b). In fact, the increase of dopamine transmission in parkinsonian patients appears to be effective in reducing motivational deficits by improving the...