DA is synthesized from the amino acid tyrosine in the neurons whose cell bodies reside in the substantia nigra (SN) and the ventral tegmental area (VTA; See Fig. 1). A small amount of DA is also produced by the hypothalamus. Sign in to download hi-res image Fig. 1. Sites of DA ...
12 More recently, evidence has been provided in support of the internalization model in the form of in vitro and ex vivo binding assays showing lowered binding affinity of many D2/D3 radiotracers for internalized receptors in cell or membrane preparations,13,14 and in a mutant mouse model ...
Social play behavior is a highly rewarding form of social interaction displayed by young mammals. Social play is important for neurobehavioral development and it has been found to be impaired in several developmental psychiatric disorders. In line with t
Every cell that appeared within the dissector height was included in the count, as long as they did not intersect with or touch the exclusion lines of the counting frame. The total numbers of TH + cells in the SN, LC, and DMV were estimated using the optical fractionator formula37. ...
Such distribution was also supported by single-molecule fluorescence in situ hybridization (smFISH), showing Drd1a mRNA expression at the border of the Purkinje cell layer (PCL) and molecular layer (ML) (Fig. 1f). We further revealed that the DA transporter (DAT) was also expressed in BGs ...
Comparative studies are imperative for understanding the evolution of adaptive neurobiological processes such as neural plasticity, cognition, and emotion. Previously we have reported that prolonged omission of expected rewards (OER, or 'frustrative nonreward') causes increased aggression in Atlantic salmon...
The dopaminergic (DA) neurons in the midbrain play a role in cognition, affect and movement. The purpose of the present study was to map and quantify the number of DA neurons in the midbrain, within the nuclei that constitute cell groups A8, A9 and A10, in the mouse. Two strains of...
The D2 short predominates in the cell bodies and projection axons of the dopaminergic cell groups of the mesencephalon and hypothalamus, whereas the D2 long is more strongly expressed by neurons in the striatum and nucleus accumbens, structures targeted by dopaminergic fibers. These results show ...
Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to analyse subtyp
cell bodies were situated within three clusters: One mostly below the lateral calyx (C3) and two (C1 and C2) below the α lobe in the inferior medial protocerebrum. Other labeled cell bodies lied dispersed or in small groups around the protocerebral bridge, below the optic tubercles, ...