Later, DA receptor agonists, such as those shown in Table1, were developed either as monotherapies or combination therapies with L-DOPA for the treatment of PD. Five types of DA receptors, D1–D5, exist in the brain. The D1and D5receptors are grouped together as D1-like receptors base...
Treatment with dopamine agonists has been linked to the development of impulse control disorders, and treatment with levodopa can cause wearing off of NMS in addition to the more commonly recognized wearing off of motor symptoms.8, 37 This finding belies the need for both a better understanding ...
From a pharmacologically different perspective within drug abuse research, the review continues with an exposition of efficacy-related differences in the behavioral effects of dopamine D[sub 1] agonists and how such differences might be exploited in different medications strategies for treating cocaine ...
RA analogs, such as 9cRA and atRA, are agonists for RXR and RAR receptors. Compared to atRA, 9cRA is a more selective agonist for RXR. Although both atRA and 9cRA are neural protective against oxygen-glucose deprivation in hippocampal neurons [37], a differential sensitivity of these two ...
In rodents, these agonists cause disrupted PPI of the acoustic startle as well as aggression and abnormal social behaviours44,45,46, which are found in the present eNRG1-pretreated mice14,15,16. Some of these opioid-induced cognitive and behavioural abnormalities have been ascribed to hyper-...
This has been observed clinically in a variety of disorders treated with DA agonists (e.g. prolactinoma and restless legs syndrome), but has been most well studied in individuals with Parkinson's disease (PD), a disorder involving progressive loss of dopaminergic neurones [179], [180], [181...
To add to the complexity of this situation, it is likely that the dual roles of β-arrestins in GPCR signaling may be subject to complex regulatory mechanisms in response to different intensity or duration of GPCR stimulation and/or potency of agonists (Nair and Sealfon, 2003). Most ...
The present invention provides methods for preparing compounds having activity as dopamine autoreceptor agonists and partial agonists at the postsynaptic dopamine D2 receptor. These compounds are useful for treating dopaminergic disorders, such as schizo
(MSNs), including expression of functional dopamine D2 receptor. By using RARα, β and γ selective agonists we show that RARγ is the functionally dominant RAR in mediating RA control of early molecular determinants of MSNs leading to formation of striatopallidal-like neurons. In contrast, ...
Administration of DA agonists such as apomorphine and L-DOPA result in rotation contralateral to the lesion while indirect agonists such as amphetamine produce rotation ipsilateral to the lesion side. The mechanism of such unilateral effects are believed to be secondary to the lack of DA and the ...