} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\beta $$\\end{document}M is studied in order to characterize the mechanism of the hydrogen atom transfer step in the conversion of dopamine into norepinephrine....
norepinephrineepinephrinedopamine-β-hydroxylaseDopamine-β-hydroxylase (DβH) deficiency is a rare autosomal dominant disorder. Due to the absence of DβH, there is a blocked conversion of dopamine into norepinephrine. The biochemical hallmark of this syndrome consists of a complete absence of plasma...
The conversion to norepinephrine was inhibited by 0.6 mM of fusaric acid, an inhibitor of dopamine-β-hydroxylase. The reaction of dopamine 3-0-sulfate with dopamine-β-hydroxylase followed Michaelis-Menten kinetics. The calculated Km was 17 mM, different from the Km for free dopamine (0.1 mM)...
Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. In the present study, we used DBH-expressing human neuroblastoma SK-N-BE(2)C and rat pheochromocytoma (...
Dopamine 尾-hydroxylase (E.C. 1.14.17.1; protein abbreviation: D尾H) catalyzes conversion of dopamine to norepinephrine. Previous work identified two expressed alleles of the gene encoding D尾H (locus symbol DBH), containing either G or T at nucleotide position 910, resulting in specification by...
Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves Dopamine-尾-hydroxylase(DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine... RM Weinshilboum,NB Thoa,DG Johnson,... - 《Science》...
Dopamine beta-hydroxylase (DBH) is the primary enzyme responsible for conversion of dopamine to norepinephrine. In their Tourette’s syndrome sample,Comings et al (1996b)examined a Taq1 restriction site polymorphism in intron 5 and found a significant association withADHDsymptom scores. Smith and co...
This decrease in ITP with norepinephrine resulted in an increased SCPP during the norepinephrine infusion when compared with dopamine (67 ± 1 mm Hg vs 65 ± 1 mm Hg respectively, P = 0.0049). Conclusion: Norepinephrine was able to maintain MAP with a lower ITP and a correspondingly higher...
Dopamine -monooxygenase (DBM) catalyses the conversion of dopamine to norepinephrine in the catecholamine biosynthetic pathway. The substrate specificity o... Alexandre Beliaev, Humberto Ferreira, David A. Learmonth, Patricio Soares-da-Silva - 《Current Enzyme Inhibition》 被引量: 32发表: 2009年 加载...
Dopamine beta Hydroxylase Antibody detects DBH which catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. DBH antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a...