Dopamine receptor binding is calf striatal membranes of 3H-dopamine and 3H-haloperidol appears to differentiate agonist and antagonist states of the receptor. Agonists and antagonists have selective affinities for dopamine and haloperidol sites respectively. In evaluating relative affinities for dopamine and...
Both the D2 receptor antagonist (a, b) and the D3 receptor agonist (c, d) impaired object discrimination and the effect of the latter was prevented by pretreatment with a D3 receptor antagonist (e, f). rodent models of learning and memory; the SND and NOR tests using selective ligands...
Pharmacological enhancement of prefrontal D1 dopamine receptor function remains a promising therapeutic approach to ameliorate schizophrenia-spectrum working memory deficits, but has yet to be rigorously evaluated clinically. This proof-of-principle stud
Martin-Iverson MT and Else D (2000) PHNO, a selective dopamine D2 receptor agonist, does not reduce prepulse inhibition of the startle reflex in rats... Martin-Iverson,T M.,Else,... - 《Psychopharmacology》 被引量: 18发表: 2000年 Regionally selective effects of intracerebral dopamine infus...
The present study uses this model to examine the motor effects of PG01042, a D3 dopamine receptor selective agonist/partial agonist, in the rat model of human LID. In Acknowledgments This research was supported by a Community Fast Track 2006 from the Michael J. Fox Foundation for Parkinson’...
From a short list of candidates in this screening, an agonist of dopamine receptor D1 (DRD1), A7763610, was selected for further validation. To assess the therapeutic potential of A77636, we first examined its ability to inhibit proliferation and migra- tion of mammary tumor cells and its ...
The dopamine receptoragonistbromocriptinelowers IOP in human eyes when administered orally or topically.97,98This effect is blocked by intravenousmetoclopramide, a dopamine2antagonist, suggesting that this agonist is truly acting through dopamine receptors.97A selective dopamine1agonist, feno...
Selective D-2 dopamine receptor agonist 来自 掌桥科研 喜欢 0 阅读量: 15 申请(专利)号: GB19840011483 申请日期: 1984-05-04 公开/公告号: GB2157950A 公开/公告日期: 1985-11-06 申请(专利权)人: * NELSON RESEARCH AND DEVELOPMENT COMPANY 发明人: ALAN S * HORN 被引量: 4 摘要: ...
It was a decade before dihydrexidine (DHX), the first selective and full D1 agonist, was described (Lovenberg et al, 1989). DHX exhibits more than ten-fold higher affinity and potency at the D1 receptor than dopamine, and full intrinsic activity in every system in which it has been ...
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site Article Open access 05 September 2024 Introduction G-protein coupled receptors (GPCRs) are one of the largest membrane protein families, encoded by more than 800 genes1. GPCRs recognize a wide range of extracellular ...