Despite this preoccupation with dopamine, certain metabolic pathways connected with its generation or disposition have still been underinvestigated, particularly in man. This paper sets out to provide a brief evaluation of the importance of four of these pathways in the human brain, L-aromatic amino...
Dopamine travels along four major pathways in the brain. These pathways are like highways with pit stops (dopamine receptors) along the way. Dopamine stops at these receptors to send and receive various messages. These messages are signals that affect movement, coordination, pleasure, and cognition...
Immunocytochemical localization of the dopamine transporter in human brain. The Journal of Comparative Neurology , 409, 38–56.Ciliax BJ, Drash GW, Staley JK, Haber S, Mobley CJ, Miller GW, Mufson EJ, Mash DC, Levey AI. Immunocytochemical localization of the dopamine transporter in human brai...
D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. Understanding dopamine signaling in human behavior requires knowledge of the distribution of all molecular components involved in dopamine pathways through... YL Hurd,M Suzuki,GC Sedvall - 《Journal of ...
Dopamine depletion and subsequent treatment with l‐DOPA, but not the long‐lived dopamine agonist pergolide, enhances activity of the Akt pathway in the r... Dysregulation of signaling pathways is believed to contribute to Parkinson's disease pathology and l -DOPA-induced motor complications. Long...
Increased DA is thought to shift the activation balance between striatalgoandno gopathways towards thegopathway13,14,39, thereby facilitating action execution vs. inhibition. In some models, separategoandno goaction weights are modeled for each action13,14. An increase in DA during choice (be ...
Fig. 2: Dopaminergic pathways in the brain. Dopaminergic pathways in the brain include the mesocortical pathway (blue) from dopaminergic neurons in ventral tegmental area (VTA) to cortex, the mesolimbic pathway (red) from VTA to nucleus accumbens, the nigrostriatal pathway (yellow) from substantia...
4. Anatomical relationship between graft-derived dopaminergic fibres and local fibre pathways in the host brain. Immunohistochemistry for TH (red) illustrates dopaminergic nigrostriatal projections at a ventral level on the intact (a) and 6-OHDA-lesioned (b–d) sides of the brain, as seen in ...
Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson disease (PD) and the molecular pathways of cell injury and d... HC Cheng,CM Ulane,RE Burke - 《Annals of Neurology》 被引量: 478发表: 2010年 Nucleus accumbens and impulsivity The multifaceted conc...
Finally, some critical unsolved challenges are raised in this field and some potential pathways are proposed to address them. 展开 关键词: Janus membranes membranes metal‐organic framework membranes nanofiltration photocatalysis polydopamine DOI: 10.1002/adfm.201705327 被引量: 5 ...