Conditional expression of the dominant-negative TGF-beta receptor type II elicits lingual epithelial hyperplasia in transgenic mice. Dev Dyn 2013; 242: 444-55.Li, F., and M. Zhou. 2013. Conditional expression of the dominant-negative TGF-b receptor type II elicits lingual epithelial hyperplasia ...
We confirmed that dominant negative TGF-β receptor type II in T lymphocytes promotes the proliferation of T cells, and significantly increases the levels of CD4+, CD8+ T cells and effector T cells, and markedly enhances the response of CTL, which may be related to the up-regulation of T-...
Anti- mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. J Immunol 2006;177(3):1655-60.Oertelt S, Lian ZX, Cheng CM et al. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta recep- tor II dominant...
Overexpression of dominant-negative receptor type-II to TGF-β inhibits collagen type I by a decrease in SMAD-2 and 3 activation: Juan Armendariz-Borunda, CUCS, University of Guadalajara, Guadalajara, Jalisco Mexico; Ivan Hernandez-Canaveral, Vidal Delgado-Rizo, Jaime Gonzalez-Cuevas, University of...
Conditional inactivation of the TGF-beta type II receptor using Cre : Lox Expression of a dominant negative type II TGF-#beta# receptor (DNIIR) in mammary epithelial cells increases the incidence of mammary carcinomas (Gorska ... A Chytil,Magnuson MA,Wright CVE,... - 《Genesis》 被引量:...
Targeting the Type I TGF-β Receptor for Treating Caveolin-3-Deficient Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1C and Muscle Wasting Disorders... Y Ohsawa,SI Nishimatsu,M Fujino,... - Springer Japan 被引量: 0发表: 2016年 Medical genetics: advances in brief: Mutations in the ...
The second disulfide bonded loop in bovine spp-24 is a highly conserved bone morphogenetic protein (BMP)-binding loop similar to that in fetuin and the BMP receptor II, and is thus defined as the transforming growth factor-β (TGF-β ) receptor II homology-1 (TRH1) domain15, which...
Moreover, this mechanism might reveal a role for treatment with losartan, an angiotensin II type 1 receptor blocker with TGFβ antagonistic effect. Surgery for skin manifestations and hernias is disappointing and should be discouraged if done purely for aesthetic reasons. The phenotype can be ...
Here, we identify a highly mechanoresponsive nuclear transport receptor (NTR), Importin-7 (Imp7), that drives the nuclear import of YAP, a key regulator of mechanotransduction pathways. Unexpectedly, YAP governs the mechanoresponse of Imp7 by forming a YAP/Imp7 complex that responds to ...
transforming growth factor beta (TGF-B) dominant negative Introduction The transforming growth factor β isoforms, TGF-β1, -β2, and -β3, are small secreted signaling proteins. Their overall structures are similar and consist of two cystine-knotted monomers tethered together by a single inter-...