Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC 50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1 , HDAC2 , and HDAC3 , respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1) . In Vitro Domatinostat tosylate signi...
Domatinostat (Synonyms: 4SC-202 free base) 纯度: 99.08% Domatinostat (4SC-202 free base) 是一种 I 型 HDAC 抑制剂,能够抑制 HDAC1,HDAC2,和 HDAC3 的活性,IC50 值分别为 1.20 μM,1.12 μM 和 0.57 μM;同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 (Lysine specific demethylase 1) 的活性。
Domatinostat tosylate(Synonyms: 4SC-202)纯度: 99.66% Domatinostat tosylate (4SC-202) 是一种 I 型HDAC抑制剂,能够抑制 HDAC1,HDAC2,和 HDAC3 的活性,IC50值分别为 1.20 μM,1.12 μM 和 0.57 μM;同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 (Lysine specific demethylase 1) 的活性。 Domatinostat ...
英文名称: 4SC-202 free base 总访问: 37 国产/进口: 进口 半年访问: 12 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 10 mM * 1 mL 最后更新: 2024-11-4 货号: HY-16012A CAS 号: 910462-43-0 参考报价: 1181 立即询价 电话咨询 ...
产品活性:Domatinostat (4SC-202 free base) 是一种 I 型 HDAC 抑制剂,能够抑制 HDAC1,HDAC2,和 HDAC3 的活性,IC50 值分别为 1.20 μM,1.12 μM 和 0.57 μM;同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 (Lysine specific demethylase 1) 的活性。 研究领域:Cell Cycle/DNA Damage | Epigenetics | Apopt...
4SC-202是一种选择性的I类HDAC抑制剂,对HDAC1,HDAC2,和HDAC3的IC50分别为1.20 μM,1.12 μM,和0.57 μM。也对Lysine specific demethylase 1 (LSD1)表现出抑制活性。Phase 1。 靶点(IC50 & Targe) HDAC1,1.20μM HDAC11,9.7μM HDAC2,1.12μM HDAC3,0.57μM HDAC5,11.3μM 体外研究 在HeLa细胞中...
Objectives: Domatinostat (4SC‐202) is a selective class I histone deacetylase inhibitor (HDACi). This phase I study investigated safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and antitumor activity in patients with advanced hematological malignancies. Methods: Domatinostat was ...
About domatinostat (4SC-202) Domatinostatis an orally administered small molecule Class I selective HDAC inhibitor with a unique mode of action that was designed to strengthen the body’s own anti-tumor immune response. Domatinostat also influences the tumo...
4SC-202 (free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供...
产品活性:Domatinostat tosylate (4SC-202) 是一种 I 型 HDAC 抑制剂,能够抑制 HDAC1,HDAC2,和 HDAC3 的活性,IC50 值分别为 1.20 μM,1.12 μM 和 0.57 μM;同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 (Lysine specific demethylase 1) 的活性。 生物活性:Domatinostat tosylate (4SC-202) 是一种选择...