Shoot meristems, which harbor a small population of stem cells, are responsible for generating new above-ground organs in plants. The proliferation and differentiation of these stem cells is regulated by a genetic pathway involving two key meristematic g
Prion-like spreading of aggregated TDP-43 structures plays key roles in the development of amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and other major neurodegenerative diseases1,2,3,4,5,6. Despite being a vital nuclear DNA and RNA binding protein regulating RNA...
The differences suggest important roles for the distinct NTD sequence of each FGF splice variant. Colocalization experiments have found that CaM and the FGFs interact with multiple NaV isoforms within cells (47, 48, 49, 50). Proteomics studies have shown that CaM and FGF12 interact with NaV1.2...
In this study, we aimed to clarify the roles of the N domain in GnT-V. For this purpose, we made a GnT-V mutant lacking the N domain (GnT-VΔN) and investigated its activity and localization. We discovered that the GnT-V N domain is required for the activity toward glycoprotein subs...
The roles of cyclophilins include small molecule binding and receptor interactions [52]. The cyclophilin may induce a structural change in the LRR-domain probably by peptidyl-prolyl cis-trans isomerase activity (confirmation by NMR will be attempted in future experiments). In a second Far Western ...
(1) they can interact with their cognate recognition sequences in nuclease-resistant chromatin prior to activation of transcription; (2) they increase local chromatin accessibility as a prelude to productive binding of other factors; and (3) they have integral roles in the establishment of cell ...
Additionally, HIV-1 IN has been shown to play important roles in several other steps during the viral life cycle, including reverse transcription, nuclear import and chromatin targeting. Interestingly, previous studies have demonstrated that the expression of HIV-1 IN induces ...
The Ansible playbooks to configure the different sections of the solution invoke a set of Roles which consume several user configurable variables. Based on the installation environment, customers can choose to modify the variables to suit their needs and proceed with the automated installation. Note:...
or C287A mutant.ILive cell imaging and quantification of DDR1 WT or locked mutant in ECs after 10 μg/ml soluble collagen I stimulation. In (F–I), data were expressed as the means ± SEM and analyzed by two-tailed Mann–Whitney test.n = 8 biological replicates.J, KLeft...
Therefore, a different interface involving other key residues must exist in the homologs if the TMH dimerization plays essential roles in their assembly or function. Unfortunately, due to the steric hindrance caused by the larger side chain of phenylalanine, only the interface involving GxxxA motif...