这一效应主要通过vHpc中PV神经元上的5-HT2A受体激动来介导。这项研究揭示了vHpc中的GABA能抑制性神经元在介导5-HT2A受体激动剂DOI的抗焦虑效应中发挥关键作用。通过结合解剖学、药理学和遗传学方法,研究表明vHpc的CA1到下托的5-HT2A受体对于DOI的抗焦虑作用是必需的。在体电生理学和光遗传学实验表明DOI增强了...
InChI1S/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H InChI keyQVFDMWGKHUFODK-UHFFFAOYSA-N Gene Informationhuman ... HTR2A(3356), HTR2B(3357), HTR2C(3358) 安全信息 象形图 警示用语:Warning-Warning ...
原价:¥5,999.90 +- 大包装询价添加到收藏夹比较SDS中文版DATASHEET 查看相关系列 5-ht1e receptor Agonist (26)5-HT1F receptor Agonist (24)5-HT2A receptor Agonist (39)5-HT2B receptor Agonist (36)5-HT2C receptor Agonist (33)所有研究领域 ...
DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum. Brain Res 1997; 761: 97-104.Sipes TE, Geyer MA (1997) DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum. Brain Res 761:97–104...
DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic properties in the pithed rat.Hubert Dabiré and Kamel Chaouche-Teyara and Claudie Cherqui and Berthe Fournier and ...
Serotonin type 2A (5-HT 2A) receptor-mediated neurotransmitter is known to activate hypothalamic–pituitary–adrenal (HPA) axis, regulate sleep–awake cycle, induce anorexia and hyperthermia. Interaction between melatonin and 5-HT 2A receptors in the regulation of the sleep–awake cycle and head-twi...
此前研究人员发现,利用致幻剂引发的5-羟色胺受体5-HT2A的激活可以在组织的血管中及肠道中产生强大的抗炎性活性,基于此研究人员表示,我们或许可以利用致幻剂来有效抵御诸如哮喘症等炎性疾病,结果显示,名为(R)-DOI的致幻剂可以有效阻断肺炎症、粘液的过度产生、气管高反应性,并且同时可以关闭参与过敏性哮喘发生的相关关...
DOI hydrochloride 是一种血清素 5-HT2A/2C 受体激动剂,对 h5-HT2A、h5-HT2C 和 h5-HT2B 受体的 Ki 值分别为 0.7 nM、2.4 nM 和 20 nM。DOI hydrochloride 可以透过血脑屏障。DOI hydrochloride 会增加小鼠的头部抽搐。 详细介绍 产品活性:DOI hydrochloride 是一种血清素 5-HT2A/2C 受体激动剂,对...
It has been shown that the administration of 5-hydroxytryptamine (5-HT) 1A receptor agonists will antagonize the catalepsy induced by dopamine D 1 or D 2 receptor blocking agents. In the present study, administration of the 5-HT 2A/C receptor agonist, 1-(2,5-dimethoxy-4-iodo)-2-aminopr...
①肠道菌群通过促进肠血清素能神经元分泌5-羟色胺(5-HT),促进Lgr5+肠干细胞(ISC)的自我更新和功能;②肠道菌群代谢物戊酸通过阻断抑制基因转录的NuRD复合物与色氨酸羟化酶2(Tph2)启动子的结合,来促进肠血清素能神经元表达Tph2,进而生成5-H...