Both chronic excess of PTH, as in hyperparathyroidism, and intermittent elevation of PTH (by daily injections) increase the number of osteoblasts; albeit, ... T Bellido,AA Ali,I Gubrij,... - 《Endocrinology》 被引量: 1119发表: 2005年 PTH receptor signalling, osteocytes and bone disease ind...
A study in mice with conditional deletion of the PTHrP in osteocytes showed that PTH failed to increase RANKL expression and thereby osteoclastogenesis, demonstrating that PTHrP is necessary for full anabolic and catabolic bone responses to PTH administration. Modulation of in vitro Osteoclast Activity ...
In primary hyperparathyroidism, there is an increase in calcium and a decrease in phosphorus. The calcium is taken from the bones, so that's why there is an increase in Ca. So does this mean that there is an increase osteoclastic activi...
In bone tissue, PTH increases osteoclast formation and bone resorption by regulating the receptor activator of nuclear factor kappa B ligant (RANKL)/osteoprotegerin (OPG) expressed in osteoblasts. Modulation of in vitro Osteoclast Activity Mediated by Different Doses of Parathyroid Hormone/Modulacion in...
However, the increase of Mg concentrations in the body may help to suppress PTH secretion and modulate the rate of bone remodeling, leading to an optimized microarchitecture and mechanical properties of newly formed bone tissue45,46. Therefore, the use of Mg implants as novel orthopae- dic ...