Problem:When we try to use the Strong Name Tool (sn.exe) to sign assemblies with strong names, we get the error "<dllname>dll does not represent a strongly named assembly" Solution:You need to specify a strong name key file before you can use the command prompt "sn.exe". For this,...
Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism. This is thought to cause the spreading of Tau pathology in AD by templated conversion of naive Tau in recipient cells into a pathological state, followed by assembly of pathological Tau ...
It is now well established that 2D cultures of cancer cells do not represent a reliable model to test anti-cancer therapies,74 but research is starting to appreciate that also a different 3D organization can affect cancer cell behavior. Indeed, cancer cells organized into 3D spheroids have a tr...
Nutritional interventions aimed at restoring the gut microbial balance could represent preventive strategies to protect the frail population from COVID-19. This narrative review presents the possible molecular mechanisms by which intestinal dysbiosis that enhances the inflammatory state could promote the ...
CENP-A is required to maintain centromere position and assembly via a two-step mechanism2. First, CENP-A deposition occurs at the beginning of G1 phase via tight regulatory mechanisms3. Second, during interphase, it is required for the assembly of a network of centromere components named the ...
assembly made the decisions. In military life it was the War Committee composed of delegates of all the guerrilla detachments which acted. To sum up, everyone took part in the collective work, to prevent the birth of a managing class which would monopolise power. And we were successful. ...
a more realistic classification system. Herein, we present a new mechanistic-based classification of endocytosis inhibitors, in which they are segregated among four distinct classes including: (i) inhibitors that disrupt endocytosis-related protein–protein interactions, and assembly or dissociation of ...
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This means considering how, as Jason Edward Lewis notes, “The bias in these systems is not a bug but rather a feature of an interlocking set of knowledge systems designed over centuries to benefit white men first and foremost” (Lewis, 2021). Proponents of this shift from bias to power ...
As the Global Education Monitoring Report 2019 observes, “lifelong learning opportunities represent half of the SDG 4 formulation but receive only a fraction of global attention” (UNESCO 2018b, p. 266). Aaron Benavot and Ashley Stepanek Lockhart point to the lack of available data for ...