Our sensitivity analysis focuses on three key variables: 1) HIV serostatus (HIV-negative or HIV-positive); 2) any “high risk sex”, which was defined as any condomless anal intercourse in the past 6 months with an HIV-discordant or status unknown partner; and 3) any injection drug use...
2010. Cross-reactive neutralizing humoral immunity does not protect from HIV type 1 disease progression. J. Infect. Dis. 201:1045-1053. doi: 10.1086/651144.Euler Z, van Gils MJ, Bunnik EM, Phung P, Schweighardt B, et al. Cross-reactive neutralizing humoral immunity does not protect from...
Mindfulness is a skill that allows us to be less reactive to what is happening in the moment. It is a way of relating to all experience—positive, negative, and neutral—such that our overall suffering diminishes and our sense of well-being increases. To be mindful is to wake up, to ...
2,13 In OP, the mean age of diagnosis is 59.0 +/- 13.6 years, with non-specific symptoms often described as a flu-like illness.5,8 In a similar fashion to COVID-19, OP symptoms are usually mild at the initial onset with subacute presentation over a few weeks.6,7 Due to the mild...
Feline immunodeficiency virus (FIV) is the feline analogue to human immunodeficiency virus (HIV) and utilizes parallel modes of receptor-mediated entry. The FIV surface glycoprotein (SU) is an important target for induction of neutralizing antibodies, an
Replication-incompetent adenoviral vectors have been extensively used as a platform for vaccine design, with at least four anti-COVID-19 vaccines authorized to date. These vaccines elicit neutralizing antibody responses directed against SARS-CoV-2 Spike protein and confer significant level of protection...
Interleukin (IL)-6, C-reactive protein (CRP), and serum IgG4 levels were significantly higher in non-survivors. Notably, an IgG4/IgG1 ratio > 0.05 and a serum IgG4 concentration > 700 mg/dL were linked to a considerably higher 30-day death rate, and serum IgG4 concentration was ...
Other tests for autoimmune conditions and infectious diseases, particularly QuantiFERON-TB, HBV and HCV viruses, human immunodeficiency virus (HIV), mumps, adenovirus, EBV, HSV, and Herpes zoster virus (HZV), were all negative. It was then suggested that dacryoadenitis might be a late ...
In addition, the neutralization of CXCL10 did not reduce the cerebral expression of mRNA for the mediators (perforin and granzyme B [GzmB]) of the cytotoxic activity of CD8+T cells in the SCID mice. Consistently, the adoptive transfer of CD8+immune T cells to chronically infected RAG1−/...
The influence of continuous (age and C reactive protein) and categorical (HIV co-infection, antiretroviral treatment and SLCO1B1 genotype) covariates other than body size on the pharmacokinetic parameters of RIF and desRIF was explored by the stepwise forward inclusion (p = 0.05) backward eliminat...