Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA Mitotic catastrophe occurs when cells enter mitosis with damaged DNA or excess centrosomes. Cells overexpres- sing the centrosome protein CP110 or depleted of cyclin F, which targets CP110 for destruction, have more than two ...
In ovarian and osteogenic sarcoma cells, G2 arrest resulted in a low level of apoptosis[20], while in the human colon carcinoma HT-29 cell line, drug-treated cells progressed into mitosis after ini- tial arrest in G2 but were unable to undergo cytokinesis and died in a process resembling...